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Title: Impotence evaluated by the use of prostaglandin E1

Abstract

We screened 80 patients at our hospital for the differential diagnosis of impotence using intracavernous injection of prostaglandin E1 (20 micrograms). The rate of positive response was 78.8 per cent (63 patients). Neither systemic reactions nor priapism occurred. However, a considerable incidence (23.8 per cent, 19 of 80 patients) of tolerable injection pain was encountered. The 133-xenon penile washout study was conducted routinely in impotent men for hemodynamic evaluation of penile vascularity. In 80 patients a positive correlation between the response of intracavernous prostaglandin E1 injection and the result of the washout study was found (r equals 0.381, p less than 0.0002). We selected 14 subjects randomly to receive additional intravenous infusions of prostaglandin E1 (6 ampules, 120 micrograms total) for 3 days, after which another 133-xenon washout study was done. The washout studies before and after intravenous prostaglandin E1 infusion were compared, and 10 patients (71.4 per cent) appeared to obtain improvement in half-time clearance and penile blood flow. However, only 3 patients noticed improvement subjectively. We suggest that prostaglandin E1 could be a desirable alternative for the diagnosis and treatment of impotence.

Authors:
; ; ; ; ; ;
Publication Date:
Research Org.:
Veterans General Hospital-Taichung, Tawan (China)
OSTI Identifier:
5877802
Resource Type:
Journal Article
Journal Name:
J. Urol.; (United States)
Additional Journal Information:
Journal Volume: 141:6
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; MALE GENITALS; BLOOD FLOW; PROSTAGLANDINS; METABOLISM; UROGENITAL SYSTEM DISEASES; DIAGNOSIS; MALES; MAN; PATIENTS; TRACER TECHNIQUES; XENON 133; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; DAYS LIVING RADIOISOTOPES; DISEASES; EVEN-ODD NUCLEI; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; MAMMALS; NUCLEI; ORGANS; PRIMATES; RADIOISOTOPES; VERTEBRATES; XENON ISOTOPES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics

Citation Formats

Hwang, T I, Yang, C R, Wang, S J, Chang, C L, Tzai, T S, Chang, C H, and Wu, H C. Impotence evaluated by the use of prostaglandin E1. United States: N. p., 1989. Web.
Hwang, T I, Yang, C R, Wang, S J, Chang, C L, Tzai, T S, Chang, C H, & Wu, H C. Impotence evaluated by the use of prostaglandin E1. United States.
Hwang, T I, Yang, C R, Wang, S J, Chang, C L, Tzai, T S, Chang, C H, and Wu, H C. 1989. "Impotence evaluated by the use of prostaglandin E1". United States.
@article{osti_5877802,
title = {Impotence evaluated by the use of prostaglandin E1},
author = {Hwang, T I and Yang, C R and Wang, S J and Chang, C L and Tzai, T S and Chang, C H and Wu, H C},
abstractNote = {We screened 80 patients at our hospital for the differential diagnosis of impotence using intracavernous injection of prostaglandin E1 (20 micrograms). The rate of positive response was 78.8 per cent (63 patients). Neither systemic reactions nor priapism occurred. However, a considerable incidence (23.8 per cent, 19 of 80 patients) of tolerable injection pain was encountered. The 133-xenon penile washout study was conducted routinely in impotent men for hemodynamic evaluation of penile vascularity. In 80 patients a positive correlation between the response of intracavernous prostaglandin E1 injection and the result of the washout study was found (r equals 0.381, p less than 0.0002). We selected 14 subjects randomly to receive additional intravenous infusions of prostaglandin E1 (6 ampules, 120 micrograms total) for 3 days, after which another 133-xenon washout study was done. The washout studies before and after intravenous prostaglandin E1 infusion were compared, and 10 patients (71.4 per cent) appeared to obtain improvement in half-time clearance and penile blood flow. However, only 3 patients noticed improvement subjectively. We suggest that prostaglandin E1 could be a desirable alternative for the diagnosis and treatment of impotence.},
doi = {},
url = {https://www.osti.gov/biblio/5877802}, journal = {J. Urol.; (United States)},
number = ,
volume = 141:6,
place = {United States},
year = {Thu Jun 01 00:00:00 EDT 1989},
month = {Thu Jun 01 00:00:00 EDT 1989}
}