Lung metastases after curative or noncurative irradiation of microscopic primary melanomas
Melanomas growing in the feet of syngeneic C57BL/6 mice were treated with a single dose of X-irradiation. After doses of 0, 3.75, 7.5, 10, 20, or 30 Gy the tumor-bearing limb was amputated at tumor sizes 1, 2, 3, 4, or 5 mm. After doses of 40, 50, 62.5, or 72.5 Gy, progressive tumor growth did not occur, and amputation of tumor-bearing limbs was done when controls were 1, 2, 3, 4, or 5 mm in size. Eighteen days after amputation the mice were killed, and pulmonary metastases were documented at autopsy. None of the mice developed pulmonary metastases after curative irradiation of the primary foot tumor. After subcurative irradiation there was a significant increase (P less than .003) in pulmonary metastases. The size of the primary melanoma is important in the prediction of these metastases. In this model melanomas can be cured by an adequate dose of irradiation, but in those not cured the incidence of lung metastases is increased. The impact of this biologic phenomenon on survival is unclear.
- Research Organization:
- Henry Ford Hospital, Detroit, MI (USA)
- OSTI ID:
- 5877311
- Journal Information:
- J. Surg. Oncol.; (United States), Vol. 41:1
- Country of Publication:
- United States
- Language:
- English
Similar Records
Stereotactic Radiosurgery for Melanoma Brain Metastases in Patients Receiving Ipilimumab: Safety Profile and Efficacy of Combined Treatment
Radioembolization for Neuroendocrine Liver Metastases: Safety, Imaging, and Long-Term Outcomes
Related Subjects
LUNGS
METASTASES
MELANOMAS
RADIOTHERAPY
RADIOINDUCTION
SIDE EFFECTS
BIOLOGICAL MODELS
DOSE-RESPONSE RELATIONSHIPS
EXPERIMENTAL NEOPLASMS
FEET
MICE
RADIATION DOSES
TUMOR CELLS
X RADIATION
ANIMAL CELLS
ANIMALS
BODY
BODY AREAS
DISEASES
DOSES
ELECTROMAGNETIC RADIATION
IONIZING RADIATIONS
LEGS
LIMBS
MAMMALS
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
RADIATIONS
RADIOLOGY
RESPIRATORY SYSTEM
RODENTS
THERAPY
VERTEBRATES
560152* - Radiation Effects on Animals- Animals