Effects of monoalkyl dithiocarbamates on mobilization of cadmium in the mouse

Journal Article · Wed Jan 01 00:00:00 EST 1986 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398609530804· OSTI ID:5877006

Jones, M M; Gale, G R; Atkins, L M; Smith, A B

Monoalkyl dithiocarbamates are capable of mobilizing cadmium from aged intracellular deposits in which the cadmium is largely present in metallothionein. The sodium salts of monomethyl, ethyl, n-propyl, and n-butyl dithiocarbamates have been prepared, characterized, and examined for their relative ability to mobilize cadmium from such aged deposits in the kidneys, liver, spleen, testes, brain, and pancreas as well as from the whole body, using sodium diethyl dithiocarbamate as the positive control. Alterations in the structure of the dithiocarbamates can be correlated with alterations in organ cadmium levels. The acute toxicity of these compounds is sufficiently greater than disubstituted dithiocarbamates that their use would appear to possess few advantages, although they do seem to be more effective in reducing testicular cadmium levels.

• Research Organization: Vanderbilt Univ., Nashville, TN
• OSTI ID: 5877006
• Journal Information: J. Toxicol. Environ. Health; (United States), Vol. 17:1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CADMIUM
REMOVAL
CHELATING AGENTS
BIOLOGICAL EFFECTS
COMPARATIVE EVALUATIONS
STRUCTURE-ACTIVITY RELATIONSHIPS
TOXICITY
BRAIN
DEDTC
KIDNEYS
LIVER
MICE
PANCREAS
SPLEEN
TESTES
ANIMALS
BODY
CARBAMATES
CARBONIC ACID DERIVATIVES
CARBOXYLIC ACID SALTS
CENTRAL NERVOUS SYSTEM
DIGESTIVE SYSTEM
ELEMENTS
ENDOCRINE GLANDS
GLANDS
GONADS
MALE GENITALS
MAMMALS
METALS
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
RODENTS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)