Influence of serotonin on fraction of lesions in DNA induced by ultraviolet light and roentgen irradiation

Journal Article · Thu Feb 20 00:00:00 EST 1986 · Biochemistry (Engl. Transl.); (United States)

OSTI ID:5874518

Ivanova, E V; Fraikin, G Ya

The influence of serotonin on the yield of thymine dimers and rupture of the N-glycoside bond (the yield of thymine in DNA irradiated with ultraviolet light and roentgen irradiation) was studied by means of two-dimensional thin-layer chromatography. It was found that serotonin bound to DNA decreases the formation of UV-induced thymine dimers, but has no effect on the number of breaks in the N-glycoside bond in thymidine residues induced by roentgen irradiation. The data obtained are discussed in terms of the question of the mechanisms of the protective effect of serotonin in the photoprotection of yeast cells against the lethal action of UV- and roentgen radiation.

• Research Organization: Lomonosov Moscow State Univ., Moscow (Russian Federation)
• OSTI ID: 5874518
• Journal Information: Biochemistry (Engl. Transl.); (United States), Vol. 50:8; Other Information: Translated from Biokhimiya; 50: No. 8, 1374-1376(Aug 1985)
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
DNA
AUTORADIOGRAPHY
BIOLOGICAL RADIATION EFFECTS
TRACER TECHNIQUES
SEROTONIN
BIOLOGICAL FUNCTIONS
CARBON 14 COMPOUNDS
CHEMICAL REACTION YIELD
DIMERS
ESCHERICHIA COLI
GAMMA RADIATION
INJURIES
LETHAL IRRADIATION
PLANT CELLS
RADIATION PROTECTION
STRAND BREAKS
THIN-LAYER CHROMATOGRAPHY
THYMINE
ULTRAVIOLET RADIATION
X RADIATION
YEASTS
AMINES
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
AZAARENES
AZINES
AZOLES
BACTERIA
BIOLOGICAL EFFECTS
CHROMATOGRAPHY
DRUGS
ELECTROMAGNETIC RADIATION
FUNCTIONS
FUNGI
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
INDOLES
IONIZING RADIATIONS
IRRADIATION
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MICROORGANISMS
NEUROREGULATORS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PLANTS
PYRIMIDINES
PYRROLES
RADIATION EFFECTS
RADIATIONS
RADIOPROTECTIVE SUBSTANCES
SEPARATION PROCESSES
SYMPATHOMIMETICS
TRYPTAMINES
URACILS
YIELDS
560120* - Radiation Effects on Biochemicals
Cells
& Tissue Culture
550201 - Biochemistry- Tracer Techniques