Irradiation of choroidal melanoma with iodine 125 ophthalmic plaque

Journal Article · Fri Aug 01 00:00:00 EDT 1980 · Arch. Ophthalmol. (Chicago); (United States)

DOI:https://doi.org/10.1001/archopht.1980.01020040305019· OSTI ID:5870330

Packer, S; Rotman, M; Fairchild, R G; Albert, D M; Atkins, H L; Chan, B

Radioactive iodine 125 is a low-energy ..gamma.. isotope with physical characteristics suitable for irradiation of intraocular tumors. Metal ophthalmic applicators have been designed to shield vital ocular structures while allowing irradiation of the tumor. We compared the radiation effects of iodine 125 and cobalt 60. The Greene melanoma was transplanted into the suprachoroidal space of rabbits. The tumor then grew as an intraocular mass, was irradiated, and was followed up for two months before enucleation. Histopathologic examiation defined the extent of the radiation damage to the tumor and other ocular structures from the iodine 125 and from the cobalt 60. The eye irradiated with iodine 125 suffered minimal radiation damage, whereas the tumor was sterilized. The eye irradiated with cobalt 60 showed substantial radiation damage, and the melanoma was incompletely treated. Our results support the use of iodine 125 in treating intraocular tumors. More research is needed as to optimum total dose and dose rate.

• DOE Contract Number: AC02-76CH00016
• OSTI ID: 5870330
• Journal Information: Arch. Ophthalmol. (Chicago); (United States), Vol. 98
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
62 RADIOLOGY AND NUCLEAR MEDICINE
EYES
BIOLOGICAL RADIATION EFFECTS
IODINE 125
ISOTOPE APPLICATIONS
MELANOMAS
RADIOTHERAPY
SIDE EFFECTS
COBALT 60
COMPARATIVE EVALUATIONS
DOSE RATES
EXTERNAL IRRADIATION
IRRADIATION DEVICES
LOCAL IRRADIATION
RABBITS
RADIATION DOSES
RADIATION SOURCES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BODY
BODY AREAS
COBALT ISOTOPES
DAYS LIVING RADIOISOTOPES
DISEASES
DOSES
ELECTRON CAPTURE RADIOISOTOPES
FACE
HEAD
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IODINE ISOTOPES
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MEDICINE
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANS
RADIATION EFFECTS
RADIOISOTOPES
RADIOLOGY
SENSE ORGANS
THERAPY
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560152* - Radiation Effects on Animals- Animals
550603 - Medicine- External Radiation in Therapy- (1980-)