Effect of atropine on oral clearance of a radiolabeled sulfur colloid

Journal Article · Thu Nov 01 00:00:00 EST 1984 · J. Lab. Clin. Med.; (United States)

OSTI ID:5863834

LaForce, F M; Thompson, B; Trow, R

Physical clearance is an important oral defense mechanism against gram-negative rods. The authors describe a simple technique that uses commercially available technetium-99m sulfur colloid to measure oral clearance. Technetium-99m sulfur colloid was sprayed into the mouth, and clearance was measured as the percent decrease in radiolabel counts over 2 hours using a radioisotope camera. Results using this technique compared favorably with clearance data using Tc-99m radiolabeled Escherichia coli. Atropine significantly decreased oral clearance rates of the colloid. Decreased clearance may be an important risk factor in the development of gram-negative rod colonization in hospitalized patients. 15 references, 3 figures.

• Research Organization: Veterans Administration Medical Center, Denver, CO
• OSTI ID: 5863834
• Journal Information: J. Lab. Clin. Med.; (United States), Vol. 104:5
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ATROPINE
BIOLOGICAL EFFECTS
BACTERIA
LABELLING
TECHNETIUM 99
CLEARANCE
COMPARATIVE EVALUATIONS
ESCHERICHIA COLI
EXPERIMENTAL DATA
ISOMERIC NUCLEI
MEASURING METHODS
ORAL ADMINISTRATION
PATIENTS
PNEUMONIA
RADIOCOLLOIDS
SULFUR COMPOUNDS
ALKALOIDS
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
COLLOIDS
DATA
DISEASES
DISPERSIONS
DRUGS
HOURS LIVING RADIOISOTOPES
INFORMATION
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MICROORGANISMS
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
PARASYMPATHOLYTICS
RADIOISOTOPES
RESPIRATORY SYSTEM DISEASES
TECHNETIUM ISOTOPES
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics