The membrane-stabilizing action of zinc carnosine (Z-103) in stress-induced gastric ulceration in rats

Journal Article · Tue Jan 01 00:00:00 EST 1991 · Life Sciences; (United States)

DOI:https://doi.org/10.1016/0024-3205(91)90321-2· OSTI ID:5863127

Cho, C H; Luk, C T; Ogle, C W ^[1]

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1. Univ. of Hong Kong (Hong Kong)

Zinc compounds have been shown to antagonize various types of gastric ulceration in rats. Zinc carnosine (Z-103), a newly developed agent was, therefore, examined for its antiulcer effect in stress-induced ulceration and also its membrane stabilizing action in rat stomachs. Cold-restraint stress induced severe hemorrhagic lesions together with increased mast cell degranulation and {beta}-glucuronidase release in the gastric glandular mucosa. A-103 pretreatment with a single oral dose reversed these actions in a dose-dependent manner. When the compound was incubated in concentrations of 10{sup {minus}7}, 10{sup {minus}6}, 10{sup {minus}5} or 10{sup {minus}4} M, with isolated hepatic lysosomes, it significantly reduced the spontaneous release of {beta}-glucuronidase in the medium. The present study not only demonstrates the antiulcer effect of Z-103 but also indicates that the protective action is likely to be mediated by its membrane-stabilizing action on mast cells and lysosomes in the gastric glandular mucosa.

• OSTI ID: 5863127
• Journal Information: Life Sciences; (United States), Vol. 49:23; ISSN 0024-3205
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
STOMACH
ULCERS
ZINC
BIOLOGICAL EFFECTS
BIOLOGICAL STRESS
DOSE-RESPONSE RELATIONSHIPS
LYSOSOMES
MAST CELLS
METABOLISM
MUCOUS MEMBRANES
RATS
ANIMAL CELLS
ANIMALS
BODY
CONNECTIVE TISSUE CELLS
DIGESTIVE SYSTEM
ELEMENTS
GASTROINTESTINAL TRACT
MAMMALS
MEMBRANES
METALS
ORGANS
PATHOLOGICAL CHANGES
RODENTS
SOMATIC CELLS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology