Childhood leukemia and parental occupation: a register-based case-control study
To explore possible etiologic factors of childhood leukemia, a case-control study was performed in the Netherlands. Cases were selected from a complete nationwide register of cases of childhood leukemia which were diagnosed between 1973 and 1980. Controls were matched with cases for year of birth, sex, and place of residence at the time of diagnosis. Information about possible exposure was collected by a postal questionnaire addressed to the parents. This report concerns the results of the analysis of parental occupations and occupational exposures for 519 children with acute lymphocytic leukemia and 507 controls. During pregnancy, more mothers of patients were working in ''hydrocarbon-related'' occupations; relative risk (RR) = 2.5 (95% confidence interval (CI) = 0.7 - 9.4). Likewise, greater occupational exposure to chemicals (paint, petroleum products, and unspecified chemicals) during pregnancy was found for mothers of patients (RR = 2.4, 95% CI = 1.2 - 4.6). The kind of work being performed by the mothers one year before diagnosis did not differ between cases and controls. For the fathers, no relationship was found between a hydrocarbon-related occupation or occupational exposure to chemicals and leukemia in the offspring. Adjustment for birth order, social class, and degree of urbanization did not materially change the relative risks. 16 references, 5 tables.
- Research Organization:
- Dutch Childhood Leukaemia Study Group, The Hague, Netherlands
- OSTI ID:
- 5862740
- Journal Information:
- Am. J. Epidemiol.; (United States), Vol. 121:2
- Country of Publication:
- United States
- Language:
- English
Similar Records
Population-based case-control study of childhood leukemia in Shanghai
Magnetic field exposure from electric appliances and childhood cancer
Related Subjects
CHEMICAL INDUSTRY
HEALTH HAZARDS
CHILDREN
LEUKEMIA
DIAGNOSIS
PAINTS
OCCUPATIONAL EXPOSURE
PETROLEUM PRODUCTS
EPIDEMIOLOGY
EXPERIMENTAL DATA
NETHERLANDS
PERSONNEL
PREGNANCY
PROGENY
RISK ASSESSMENT
AGE GROUPS
COATINGS
DATA
DISEASES
EUROPE
HAZARDS
HEMIC DISEASES
INDUSTRY
INFORMATION
NEOPLASMS
NUMERICAL DATA
WESTERN EUROPE
560306* - Chemicals Metabolism & Toxicology- Man- (-1987)