Disposition of perfluorodecanoic acid in male and female rats

Journal Article · Fri Mar 01 00:00:00 EST 1991 · Toxicology and Applied Pharmacology; (USA)

DOI:https://doi.org/10.1016/0041-008X(91)90308-2· OSTI ID:5855664

Vanden Heuvel, J P; Kuslikis, B I; Van Rafelghem, M J; Peterson, R E ^[1]

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1. Univ. of Wisconsin, Madison (USA)

The elimination, tissue distribution, and metabolism of (1-14C)PFDA were examined in male and female rats for 28 days after a single ip dose (9.4 mumol/kg, 5 mg/kg). A sex difference in the fecal elimination of perfluorodecanoic acid (PFDA) was observed with 51 and 24% of the administered 14C being recovered in the feces of male and female rats, respectively, by 28 days post-treatment. The cumulative excretion of PFDA-derived 14C in the urine in 28 days was less than 5% of the administered dose in both sexes. The sex-related difference in the rate of fecal elimination resulted in the observed difference in whole body elimination t1/2 of PFDA in males (t1/2 = 23 days) and females (t1/2 = 45 days). The liver contained the highest concentration of PFDA-derived 14C in both males and females, followed by the plasma and kidneys. The heart, fat pads, testes, and gastrocnemius muscle of males, and the ovaries of females contained much lower concentrations of PFDA. The reason for the high percentage of the ip dose of (1-14C)PFDA in the liver (53% males and 41% females, 2 hr post-treatment) was further examined using an in situ nonrecirculating liver perfusion technique. It was shown that approximately 25% of the (14C)PFDA in the perfusate was extracted by the liver in a single pass. The basis for the sex difference in fecal elimination of PFDA does not appear to be due to a sex difference in biliary excretion. In a 6-hr period, male and female rats with kidneys ligated eliminated essentially the same percentage dose of (14C)PFDA into bile. We had hypothesized that the persistence of PFDA in rats was due to formation of a PFDA-containing lipids. However, no evidence that PFDA is conjugated to form persistent hybrid lipids was obtained, nor were polar metabolites of PFDA detected in urine or bile.

• OSTI ID: 5855664
• Journal Information: Toxicology and Applied Pharmacology; (USA), Vol. 107:3; ISSN 0041-008X
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
DECANOIC ACID
METABOLISM
CARBON 14 COMPOUNDS
LIPIDS
LIQUID COLUMN CHROMATOGRAPHY
RATS
SEX DEPENDENCE
TISSUE DISTRIBUTION
TRACER TECHNIQUES
ANIMALS
CARBOXYLIC ACIDS
CHROMATOGRAPHY
DISTRIBUTION
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MONOCARBOXYLIC ACIDS
ORGANIC ACIDS
ORGANIC COMPOUNDS
RODENTS
SEPARATION PROCESSES
VERTEBRATES
550501* - Metabolism- Tracer Techniques