In vivo quantitation of platelet deposition on human peripheral arterial bypass grafts using indium-111-labeled platelets. Effect of dipyridamole and aspirin

Journal Article · Tue Mar 01 00:00:00 EST 1983 · Am. J. Cardiol.; (United States)

DOI:https://doi.org/10.1016/S0002-9149(83)80136-2· OSTI ID:5855073

Pumphrey, C W; Chesebro, J H; Dewanjee, M K; Wahner, H W; Hollier, L H; Pairolero, P C; Fuster, V

Indium-111-labeled autologous platelets, injected 48 hours after operation, were used to evaluate the thrombogenicity of prosthetic material and the effect of platelet inhibitor therapy in vivo. Dacron double-velour (Microvel) aortofemoral artery bifurcation grafts were placed in 16 patients and unilateral polytetrafluoroethylene femoropopliteal grafts were placed in 10 patients. Half the patients in each group received platelet inhibitors before operation (dipyridamole, 100 mg 4 times a day) and after operation (dipyridamole, 75 mg, and acetylsalicylic acid, 325 mg 3 times a day); the rest of the patients served as control subjects. Five-minute scintigrams of the graft region were taken with a gamma camera interfaced with a computer 48, 72, and 96 hours after injection of the labeled platelets. Platelet deposition was estimated from the radioactivities of the grafts and expressed as counts per 100 pixels per microcurie injected. Dipyridamole and aspirin therapy significantly reduced the number of platelets deposited on Dacron grafts and prevented platelet accumulation over 3 days. With the small amount of platelet deposition on polytetrafluoroethylene femoropopliteal artery grafts even in control patients, platelet inhibitor therapy had no demonstrable effect on platelet deposition on these grafts. It is concluded that (1) platelet deposition on vascular grafts in vivo can be quantitated by noninvasive methods, and (2) dipyridamole and aspirin therapy reduced platelet deposition on Dacron aortofemoral artery grafts.

• Research Organization: Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, Minnesota
• OSTI ID: 5855073
• Journal Information: Am. J. Cardiol.; (United States), Vol. 51:5
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ARTERIES
SCINTISCANNING
BLOOD PLATELETS
INHIBITION
GRAFTS
ACETYLSALICYLIC ACID
ANTICOAGULANTS
DACRON
DEPOSITION
GRAFT-HOST REACTION
INDIUM 111
LABELLED COMPOUNDS
MONITORING
ANALGESICS
ANTIPYRETICS
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD VESSELS
BODY
BODY FLUIDS
CARBOXYLIC ACIDS
CARDIOVASCULAR SYSTEM
CENTRAL NERVOUS SYSTEM DEPRESSANTS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
ESTERS
HEMATOLOGIC AGENTS
HYDROXY ACIDS
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MATERIALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC POLYMERS
ORGANS
POLYESTERS
POLYMERS
RADIOISOTOPE SCANNING
RADIOISOTOPES
TRANSPLANTS
550601* - Medicine- Unsealed Radionuclides in Diagnostics