Lumbar cerebrospinal fluid concentrations of somatostatin and neuropeptide Y in multiple sclerosis

Vecsei, L; Csala, B; Widerloev, E E; Ekman, R; Czopf, J; Palffy, G

doi:10.1016/0361-9230(90)90229-S

Title: Lumbar cerebrospinal fluid concentrations of somatostatin and neuropeptide Y in multiple sclerosis

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Abstract

The cerebrospinal fluid (CSF) concentrations of somatostatin and neuropeptide Y were investigated by use of radioimmunoassay in patients suffering from chronic progressive multiple sclerosis. The somatostatin level was significantly decreased in the CSF of patients with multiple sclerosis compared to the control group. The magnitude of this change was more pronounced in patients with severe clinical symptoms of the illness. The CSF neuropeptide Y concentration did not differ from the control values. These findings suggest a selective involvement of somatostatin neurotransmission in multiple sclerosis.

Authors:

Vecsei, L; Csala, B; Widerloev, E E; Ekman, R; Czopf, J; Palffy, G ^[1]

Univ. of Lund (Sweden)

Publication Date:: Sat Sep 01 00:00:00 EDT 1990

OSTI Identifier:: 5853146

Resource Type:: Journal Article

Journal Name:: Brain Research Bulletin; (USA)

Additional Journal Information:: Journal Volume: 25:3; Journal ID: ISSN 0361-9230

Country of Publication:: United States

Language:: English

Subject:: 59 BASIC BIOLOGICAL SCIENCES; CEREBROSPINAL FLUID; CHEMICAL COMPOSITION; NERVOUS SYSTEM DISEASES; PATHOGENESIS; PEPTIDES; RADIOIMMUNOASSAY; SOMATOSTATIN; IODINE ISOTOPES; PATIENTS; BIOASSAY; BIOLOGICAL MATERIALS; BODY FLUIDS; DIAGNOSTIC TECHNIQUES; DISEASES; IMMUNOASSAY; IMMUNOLOGY; ISOTOPE APPLICATIONS; ISOTOPES; MATERIALS; ORGANIC COMPOUNDS; PROTEINS; RADIOASSAY; RADIOIMMUNODETECTION; RADIOIMMUNOLOGY; TRACER TECHNIQUES; 550901* - Pathology- Tracer Techniques

Citation Formats


                    Vecsei, L, Csala, B, Widerloev, E E, Ekman, R, Czopf, J, and Palffy, G. Lumbar cerebrospinal fluid concentrations of somatostatin and neuropeptide Y in multiple sclerosis.  United States: N. p., 1990. 
        Web.  doi:10.1016/0361-9230(90)90229-S.

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                    Vecsei, L, Csala, B, Widerloev, E E, Ekman, R, Czopf, J, & Palffy, G. Lumbar cerebrospinal fluid concentrations of somatostatin and neuropeptide Y in multiple sclerosis.  United States.  https://doi.org/10.1016/0361-9230(90)90229-S

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                    Vecsei, L, Csala, B, Widerloev, E E, Ekman, R, Czopf, J, and Palffy, G. 1990.  
        "Lumbar cerebrospinal fluid concentrations of somatostatin and neuropeptide Y in multiple sclerosis".  United States.  https://doi.org/10.1016/0361-9230(90)90229-S.

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@article{osti_5853146,

  title        = {Lumbar cerebrospinal fluid concentrations of somatostatin and neuropeptide Y in multiple sclerosis},

  author       = {Vecsei, L and Csala, B and Widerloev, E E and Ekman, R and Czopf, J and Palffy, G},

  abstractNote = {The cerebrospinal fluid (CSF) concentrations of somatostatin and neuropeptide Y were investigated by use of radioimmunoassay in patients suffering from chronic progressive multiple sclerosis. The somatostatin level was significantly decreased in the CSF of patients with multiple sclerosis compared to the control group. The magnitude of this change was more pronounced in patients with severe clinical symptoms of the illness. The CSF neuropeptide Y concentration did not differ from the control values. These findings suggest a selective involvement of somatostatin neurotransmission in multiple sclerosis.},

  doi          = {10.1016/0361-9230(90)90229-S},

  url          = {https://www.osti.gov/biblio/5853146},
  journal      = {Brain Research Bulletin; (USA)},

  issn         = {0361-9230},

  number       = ,

  volume       = 25:3,

  place        = {United States},

  year         = {Sat Sep 01 00:00:00 EDT 1990},

  month        = {Sat Sep 01 00:00:00 EDT 1990}

}

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