Estimating the mass of mutagens in indeterminate mixtures

Journal Article · Tue Oct 01 00:00:00 EDT 1985 · Ecotoxicol. Environ. Saf.; (United States)

DOI:https://doi.org/10.1016/0147-6513(85)90065-X· OSTI ID:5842869

Schaeffer, D J; Kerster, H W

A method is shown for estimating the quantity (mass) of genotoxic compounds in complex mixtures without prior identification of components. This method uses fractiles of the probability distribution of responses from the assay of interest and dose-response of the mixture. The method depends upon the assumption of additivity, on average, in the interaction of mutagens and on lognormality of the distribution of mutagen molecular weights. Mass estimates are necessary for hazard characterization, risk estimation, and risk assessment. The method is illustrated using Ames assay results from a coke plant wastewater.

• Research Organization: Illinois Environmental Protection Agency, Springfield
• OSTI ID: 5842869
• Journal Information: Ecotoxicol. Environ. Saf.; (United States), Vol. 2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
WASTE WATER
MUTAGEN SCREENING
COKE
COKING PLANTS
DOSE-RESPONSE RELATIONSHIPS
MUTAGENS
RISK ASSESSMENT
SALMONELLA TYPHIMURIUM
BACTERIA
HYDROGEN COMPOUNDS
INDUSTRIAL PLANTS
LIQUID WASTES
MICROORGANISMS
OXYGEN COMPOUNDS
SALMONELLA
SCREENING
WASTES
WATER
560302* - Chemicals Metabolism & Toxicology- Microorganisms- (-1987)