Amino acids as central synaptic transmitters or modulators in mammalian thermoregulation
Of the amino acids that affect the activity of central neurons, aspartate and glutamate (which exert generally excitatory influences) and glycine, taurine, and ..gamma..-aminobutyric acid (GABA) (which generally exert inhibitory influences) are the strongest neurotransmitter candidates. As with other putative transmitter substances, their effects on body temperature when injected into the cerebral ventricles or the preoptic hypothalamus tend to vary within and between species. These effects are uninterpretable without accompanying information regarding effector activity changes and the influences of dose and ambient temperature. Observations necessary for analysis of apparent action have been made in studies of the effects of intracerebroventricular injections of these amino acids into sheep. Aspartate and glutamate have similar excitatory effects on the pathway from cold sensors, whereas taurine and GABA exert inhibitory influences on the neural pathways that activate both heat production and heat loss effectors. Glycine appears to be without effect.
- Research Organization:
- Univ. of Alaska, Fairbanks
- OSTI ID:
- 5841533
- Journal Information:
- Fed. Proc.; (United States), Vol. 40:3; Conference: Newer putative central neurotransmitters: roles in thermoregulation, Atlanta, GA, USA, 14 Apr 1981
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
NEUROREGULATORS
DYNAMIC FUNCTION STUDIES
THERMOREGULATION
BIOLOGICAL PATHWAYS
AMINO ACIDS
CEREBRUM
HYPOTHALAMUS
NERVE CELLS
SHEEP
ANIMAL CELLS
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BODY
BRAIN
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM
CONTROL
DOMESTIC ANIMALS
DRUGS
MAMMALS
NERVOUS SYSTEM
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
RUMINANTS
SOMATIC CELLS
TEMPERATURE CONTROL
VERTEBRATES
560205* - Thermal Effects- Vertebrates- (-1987)
550100 - Behavioral Biology