Effect of water pollutants and other chemicals upon ribonuclease activity in vitro

Journal Article · Tue Dec 01 00:00:00 EST 1981 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/0013-9351(81)90204-8· OSTI ID:5841498

Christensen, G M; Olson, D L

Ribonuclease was treated in vitro with 73 chemicals, many of which are environmental pollutants, including inorganic, organic, and metal-organic chemicals, pesticides and other biocides, alkyl and aryl industrial pollutants, and certain additional chemicals, to determine their effect upon enzyme activity. Palladium (II and IV) and gold (III) were the strongest inhibitors of RNase activity. Other strong inhibitors, in decreasing order of effect, were: sodium dodecyl sulfate, silver (I), EDTA, mercury (II), copper (II), thiram (fungicide), platinum (IV), malathion (pesticide), lead (II), and beryllium (II). Intermediate effects were found with other inorganic cations, many anions, and some other chemicals. A number of compounds of different chemical types caused no measureable effect. None of the chemicals tested caused a measureable activation of this enzyme.

• Research Organization: Environmental Protection Agency Environmental Research Lab., Duluth, MN
• OSTI ID: 5841498
• Journal Information: Environ. Res.; (United States), Vol. 26:2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BERYLLIUM
BIOLOGICAL EFFECTS
COPPER
EDTA
GOLD
LEAD
MALATHION
MERCURY
PALLADIUM
INHIBITION
PLATINUM
RNA-ASE
ENZYME INHIBITORS
WATER POLLUTION
ALKALINE EARTH METALS
AMINO ACIDS
CARBOXYLIC ACID ESTERS
CARBOXYLIC ACIDS
CHELATING AGENTS
ELEMENTS
ENZYMES
ESTERASES
ESTERS
HYDROLASES
INSECTICIDES
METALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANIC SULFUR COMPOUNDS
PESTICIDES
PHOSPHODIESTERASES
PLATINUM METALS
POLLUTION
THIOLS
TRANSITION ELEMENTS
560301* - Chemicals Metabolism & Toxicology- Cells- (-1987)