Therapeutic use of /sup 131/I-metaiodobenzylguanidine (MIBG) in neuroblastoma: a phase II study in nine patients

Journal Article · Thu Jan 01 00:00:00 EST 1987 · Med. Pediatr. Oncol.; (United States)

DOI:https://doi.org/10.1002/mpo.2950150414· OSTI ID:5840559

Hartmann, O; Lumbroso, J; Lemerle, J; Schlumberger, M; Ricard, M; Aubert, B; Coonaert, S; Merline, L; Olive, D; De Lumley, L

Effects of high activities of I 131 meta-iodobenzylguanidine (mIBG) were evaluated in nine children with advanced neuroblastoma. All patients had been previously heavily treated and had either primarily refractory disease or resistant relapse. Twenty-two doses of mIBG labeled with 1.3 to 4 GBq (35-108 mCi) of iodine 131 were administered. Three subjective effects, especially relief of pain, and two objective effects were observed. Transient blood pressure increase was observed once and did not recur after prolongation of the infusion time to 6 hours. A major side effect was bone marrow toxicity, essentially marked by thrombopenia, particularly severe in previously bone-marrow-transplanted patients.

• Research Organization: Institut Gustave Roussy, Villejuif, France
• OSTI ID: 5840559
• Journal Information: Med. Pediatr. Oncol.; (United States), Vol. 15:4
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
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