Transfusion-associated graft-versus-host disease

Journal Article · Sat Sep 01 00:00:00 EDT 1990 · Yale Journal of Biology and Medicine; (USA)

OSTI ID:5839612

Rappeport, J M ^[1]

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1. Yale Univ. School of Medicine, New Haven, CT (USA)

The clinical pathologic syndrome of graft-versus-host disease (GVHD) is usually a sequela of bone marrow transplantation. This disorder occurs as a result of recognition by engrafted donor-derived lymphocytes of foreign recipient transplantation antigens. GVHD may also result from engraftment of lymphocytes from other sources, including (1) transfusion of lymphocytes containing blood components, (2) transplacental maternal fetal transfusion, and (3) passive transfer of lymphocytes in solid organ transplantation. The recipients are usually severely immunodeficient and thus incapable of rejecting the transfused lymphocytes. This syndrome may, however, also develop in immunologically competent patients receiving blood products from individuals with histocompatibility antigens not recognized as foreign. 58 refs.

• OSTI ID: 5839612
• Journal Information: Yale Journal of Biology and Medicine; (USA), Vol. 63:5; ISSN 0044-0086
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BLOOD PLATELETS
TRANSFUSIONS
BONE MARROW CELLS
TRANSPLANTS
IMMUNITY
RADIOINDUCTION
BIOLOGICAL RADIATION EFFECTS
DOSE-RESPONSE RELATIONSHIPS
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ELECTROMAGNETIC RADIATION
LEUKOCYTES
MATERIALS
RADIATION EFFECTS
RADIATIONS
SOMATIC CELLS
THERAPY
560120* - Radiation Effects on Biochemicals
Cells
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