Analysis of spontaneous chromosomal rearrangements in neuroblasts of genetically unstable mutant lines of Drosophila melanogaster

Journal Article · Tue Nov 01 00:00:00 EST 1988 · Sov. Genet. (Engl. Transl.); (United States)

OSTI ID:5826660

Derzhavets, E M; Kim, A I; Aslanyan, M M

The spectrum and frequency of chromosomal aberrations in the somatic cells of III instar larvae of Drosophila melanogaster mutator line were studied using three of its derivatives (sbt, if, and w/sup a/) and line w as control. It has been demonstrated that the frequency of anaphases with bridges and acentric fragments increases in the neuroblast of flies of the mutator line as well as in the neuroblasts of the larvae of the lines sbt, if, and w/sup a/. The metaphase analysis revealed that the mutator line and its derivatives are characterized by higher frequencies of chromosomal aberrations as compared to the control. Chromatid breaks are predominant type of rearrangements. These results, suggest probably presence of the specific mutator factor or factors in the line studied, affecting chromosomal structure and, possibly, activating migration of the mobile genetic elements in the mutator line.

• Research Organization: M.V. Lomonosov Moscow State Univ. (USSR)
• OSTI ID: 5826660
• Journal Information: Sov. Genet. (Engl. Transl.); (United States), Vol. 24:5; Other Information: Translated from Genetika; 24: No. 5, 857-866(May 1988)
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
CHROMOSOMAL ABERRATIONS
STRUCTURAL CHEMICAL ANALYSIS
DROSOPHILA
MUTANTS
GENE MUTATIONS
NERVE CELLS
SPONTANEOUS MUTATIONS
CHROMATIDS
CHROMOSOME BREAKAGE
CYTOLOGY
GANGLIONS
GENETIC EFFECTS
GENETICS
INSTABILITY
LARVAE
MITOSIS
MORPHOLOGICAL CHANGES
MUTATION FREQUENCY
REVERTANTS
SISTER CHROMATID EXCHANGES
ANIMAL CELLS
ANIMALS
ARTHROPODS
BIOLOGICAL EFFECTS
BIOLOGY
CELL DIVISION
DIPTERA
FLIES
FRUIT FLIES
INSECTS
INVERTEBRATES
MUTATIONS
NERVOUS SYSTEM
SOMATIC CELLS
550400* - Genetics
550300 - Cytology