Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias

Journal Article · Sun Dec 01 00:00:00 EST 1991 · Proceedings of the National Academy of Sciences of the United States of America; (United States)

DOI:https://doi.org/10.1073/pnas.88.23.10735· OSTI ID:5823175

Ziemin-van der Poel, S; McCabe, N R; Gill, H J; Espinosa, R III; Patel, Y; Harden, A; Rubinelli, P; Smith, S D; LeBeau, M M; Rowley, J D; Diaz, M O ^[1]

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1. Univ. of Chicago, IL (United States)

Recurring chromosomal translocations involving chromosome 11, band q23, have been observed in acute lymphoid leukemias and especially in acute myeloid leukemias. The authors recently showed that breakpoints in four 11q23 translocations, t(4,11)(q21;q23), t(6;11)(q27;q23), t(9;11)(p22;q23), and t(11;19)(q23;p13.3), were contained within a yeast artificial chromosome clone bearing the CD3D and CD3G gene loci. They have identified within the CD3 yeast artificial chromosome a transcription unit that spans the breakpoint junctions of the 4;11, 9;11, and 11;19 translocations, and they describe two other, related transcripts that are upregulated in the RS4;11 cell line. They have named this gene MLL (myeloid/lymphoid, or mixed-lineage, leukemia).

• OSTI ID: 5823175
• Journal Information: Proceedings of the National Academy of Sciences of the United States of America; (United States), Vol. 88:23; ISSN 0027-8424
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
CHROMOSOMAL ABERRATIONS
DNA SEQUENCING
HETEROCHROMOSOMES
GENETIC MAPPING
DNA HYBRIDIZATION
FLUORESCENCE
GENES
LEUKEMIA
PHORBOL ESTERS
PHOSPHORUS 32
PLACENTA
TRANSLOCATION
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CARCINOGENS
CHROMOSOMES
DAYS LIVING RADIOISOTOPES
DISEASES
ESTERS
FETAL MEMBRANES
HYBRIDIZATION
IMMUNE SYSTEM DISEASES
ISOTOPES
LIGHT NUCLEI
LUMINESCENCE
MAPPING
MEMBRANES
MUTATIONS
NEOPLASMS
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
PHOSPHORUS ISOTOPES
RADIOISOTOPES
STRUCTURAL CHEMICAL ANALYSIS
550200* - Biochemistry