Chemical aspects of labeling sucralfate with /sup 99m/TcO/sub 4/
Two formulations of (/sup 99m/Tc)sucralfate have been used to image gastric and duodenal ulcers and inflammatory bowel disease. One formulation is a complexation of (/sup 99m/Tc)HSA with sucralfate. The second is prepared by directly labeling sucralfate with (/sup 99m/Tc)pertechnetate in the presence of stannous ion. An in vitro study of the factors affecting the production and stability of these labeled sucralfate preparations was conducted. Both formulations were stable at the acidic pH likely encountered in the stomach. However, at pH greater than 6 the albumin-sucralfate complex began to dissociate while directly labeled sucralfate was stable to a pH of 9. Conversely it was shown that directly labeled sucralfate was more susceptible to loss of /sup 99m/Tc to other chelating species. Sucralfate complexed with (/sup 99m/Tc)HSA was radiochemically stable up to a specific activity of 26 GBq (700 mCi) per gram while directly labeled sucralfate showed decreased 24-hr stability at specific activities greater than 837 mCi (31 GBq) per gram.
- Research Organization:
- Health Sciences Centre, Winnipeg, Manitoba (Canada)
- OSTI ID:
- 5820918
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 30:4
- Country of Publication:
- United States
- Language:
- English
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DIGESTIVE SYSTEM DISEASES
DIAGNOSIS
RADIOPHARMACEUTICALS
STABILITY
ALBUMINS
ISOMERIC NUCLEI
ORGANOMETALLIC COMPOUNDS
PERTECHNETATES
STOMACH
TECHNETIUM 99
ULCERS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
DIGESTIVE SYSTEM
DISEASES
DRUGS
GASTROINTESTINAL TRACT
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
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LABELLED COMPOUNDS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
PATHOLOGICAL CHANGES
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REFRACTORY METAL COMPOUNDS
TECHNETIUM COMPOUNDS
TECHNETIUM ISOTOPES
TRANSITION ELEMENT COMPOUNDS
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics