Work in progress. Gastrointestinal ulcerations: detection using a technetium-99m-labeled ulcer-avid agent

Journal Article · Fri Jul 01 00:00:00 EDT 1983 · Radiology; (United States)

DOI:https://doi.org/10.1148/radiology.148.1.6856841· OSTI ID:5820765

Vasquez, T E; Bridges, R L; Braunstein, P; Jansholt, A L; Meshkinpour, H

Technetium-99m-labeled sucralfate, an ulcer-avid material, was shown in preliminary animal and human studies to be stable in vivo with good sensitivity. Eight experimentally produced discrete gastric ulcers in three rabbits were visualized using this material. Of seven human studies, four studies were true-positive and three were true-negative. It is suggested that Tc-99m-labeled sucralfate may prove to have significant clinical advantages for the evaluation of gastrointestinal ulcer disease and other diseases that are associated with loss of mucosal integrity. The method for labeling sucralfate with Tc-99m was developed by the authors.

• Research Organization: Univ. of California, Irvine
• OSTI ID: 5820765
• Journal Information: Radiology; (United States), Vol. 148:1
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
GASTROINTESTINAL TRACT
SCINTISCANNING
TECHNETIUM 99
DIAGNOSTIC USES
ULCERS
DIAGNOSIS
DISACCHARIDES
ISOMERIC NUCLEI
RABBITS
TISSUE DISTRIBUTION
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CARBOHYDRATES
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISTRIBUTION
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
NUCLEI
ODD-EVEN NUCLEI
OLIGOSACCHARIDES
ORGANIC COMPOUNDS
PATHOLOGICAL CHANGES
RADIOISOTOPE SCANNING
RADIOISOTOPES
SACCHARIDES
TECHNETIUM ISOTOPES
USES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics