Differential radioactivity monitor for non-invasive detection of ocular melanoma

Lambrecht, R M; Packer, S

Title: Differential radioactivity monitor for non-invasive detection of ocular melanoma

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Abstract

There is described an apparatus and method for diagnosing ocular cancer that is both non-invasive and accurate which comprises two radiation detectors positioned before each of the patient's eyes which will measure the radiation level produced in each eye after the administration of a tumor-localizing radiopharmaceutical such as gallium-67.

Inventors:: Lambrecht, R M; Packer, S

Publication Date:: Thu Sep 23 00:00:00 EDT 1982

OSTI Identifier:: 5820142

Application Number:: ON: DE83018058

Assignee:: ERA-08-054977; EDB-83-179593

DOE Contract Number:: AC02-76CH00016

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: 62 RADIOLOGY AND NUCLEAR MEDICINE; NEOPLASMS; DIAGNOSTIC TECHNIQUES; RADIOPHARMACEUTICALS; BIOLOGICAL LOCALIZATION; EYES; GALLIUM 67; RADIATION DETECTORS; BETA DECAY RADIOISOTOPES; BODY; BODY AREAS; DAYS LIVING RADIOISOTOPES; DISEASES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; FACE; GALLIUM ISOTOPES; HEAD; INTERMEDIATE MASS NUCLEI; ISOTOPES; LABELLED COMPOUNDS; MEASURING INSTRUMENTS; NUCLEI; ODD-EVEN NUCLEI; ORGANS; RADIOISOTOPES; SENSE ORGANS; 550601* - Medicine- Unsealed Radionuclides in Diagnostics

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                    Lambrecht, R M, and Packer, S. Differential radioactivity monitor for non-invasive detection of ocular melanoma.  United States: N. p., 1982. 
        Web.

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                    Lambrecht, R M, & Packer, S. Differential radioactivity monitor for non-invasive detection of ocular melanoma.  United States.

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                    Lambrecht, R M, and Packer, S. 1982.  
        "Differential radioactivity monitor for non-invasive detection of ocular melanoma".  United States.

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@article{osti_5820142,

  title        = {Differential radioactivity monitor for non-invasive detection of ocular melanoma},

  author       = {Lambrecht, R M and Packer, S},

  abstractNote = {There is described an apparatus and method for diagnosing ocular cancer that is both non-invasive and accurate which comprises two radiation detectors positioned before each of the patient's eyes which will measure the radiation level produced in each eye after the administration of a tumor-localizing radiopharmaceutical such as gallium-67.},

  doi          = {},

  url          = {https://www.osti.gov/biblio/5820142},
  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {Thu Sep 23 00:00:00 EDT 1982},

  month        = {Thu Sep 23 00:00:00 EDT 1982}

}

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Method for non-invasive detection of ocular melanoma

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An apparatus and method is disclosed for diagnosing ocular cancer that is both non-invasive and accurate. The apparatus comprises two radiation detectors positioned before each of the patient's eyes which will measure the radiation level produced in each eye after the administration of a tumor-localizing radiopharmaceutical such as gallium-67. 2 figs.
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There is described an apparatus and method for diagnosing ocular cancer that is both non-invasive and accurate which comprises two radiation detectors positioned before each of the patient's eyes which will measure the radiation level produced in each eye after the administration of a tumor-localizing radiopharmaceutical such as gallium-67.
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Metal isotopes used as radioactive indicators of ocular melanoma

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We studied radioactive metal compounds to determine their localization in malignant Greene melanoma in the eye of the Syrian golden hamsters. Scintigraphy of an ocular melanoma was achieved with several radioactive metals: radioactive (/sup 111/In)-bleomycin, radioactive gallium (/sup 67/Ga)-citrate, and radioactive lead (/sup 203/Pb)-tris. The /sup 111/In-bleomycin had the highest tumor uptake (5.45% dose/g), but not the highest tumor-to-background ratios. The /sup 67/Ga-citrate had a maximum tumor uptake of 4.87% dose/g at 48 hours. The /sup 111/In-chloride had a melanoma uptake of 2.26% dose/g, while with /sup 203/Pb-tris the uptake was 1.61% dose/g. These uptake ratios compare favorably with thatmore »« less
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The biodistribution of over 30 radiopharmaceuticals thought to be tumor-seeking agents were studied using hamsters and mice. Several radiopharmaceuticals were found to be appropriate as melanoma localizing agents. Results with modified dual pinhole collimator and a pigment affinic agent (iodine-123 labeled quinoline) and a non-specific tumor seeking agent (gallium-67 citrate) are also reported.
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