Radionuclide imaging of experimental atherosclerosis with nonspecific polyclonal immunoglobulin G
The utility of nonspecific polyclonal IgG for external imaging of experimental atherosclerosis was tested in a series of rabbits after balloon catheter deendothelialization of the abdominal aorta. Following injection of /sup 111/In-IgG, /sup 111/In-Fc, or /sup 111/In-Fab serial images were recorded. In addition, several animals received /sup 125/I-low density lipoproteins (/sup 125/I-LDL), or /sup 125/I human serum albumin (/sup 125/I-HSA) as positive and negative controls. Forty-eight hours after injection of the radiolabeled proteins, the aortas were removed, divided into abdominal and thoracic regions, counted, and autoradiographed. The images acquired after injection of /sup 111/In-IgG and /sup 111/In-Fc, showed clear focal accumulation of radioactivity in the healing abdominal aorta. In contrast, the images obtained after injection of /sup 111/In-Fab did not show focal radionuclide accumulation. For /sup 111/In-IgG and /sup 111/In-Fc there were three to six times as many counts in the abdominal as in the thoracic aorta, while for /sup 111/In-Fab and /sup 125/I HSA, the abdominal and thoracic counts were nearly equal. The results suggest that radiolabeled IgG and Fc can be used to image experimental atherosclerosis.
- Research Organization:
- Massachusetts General Hospital, Boston (USA)
- OSTI ID:
- 5819970
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 30:6
- Country of Publication:
- United States
- Language:
- English
Similar Records
Accumulation of native and methylated low density lipoproteins by healing rabbit arterial wall
Localization of Fc and Fab fragments of nonspecific polyclonal IgG at focal sites of inflammation
Related Subjects
ARTERIOSCLEROSIS
DIAGNOSIS
IMMUNOGLOBULINS
SPECIFICITY
ABDOMEN
ALBUMINS
AORTA
AUTORADIOGRAPHY
BIOLOGICAL ACCUMULATION
CHEST
INDIUM 111
IODINE 125
LIPOPROTEINS
RABBITS
ANIMALS
ARTERIES
BETA DECAY RADIOISOTOPES
BLOOD VESSELS
BODY
BODY AREAS
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
DAYS LIVING RADIOISOTOPES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
GLOBULINS
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LIPIDS
MAMMALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RADIOISOTOPES
VASCULAR DISEASES
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics