In vivo dissolution measurement with indium-111 summation peak ratios
Dissolution of (/sup 111/In)labeled tablets was measured in vivo in a totally noninvasive manner by using a modification of the perturbed angular correlation technique known as the summation peak ratio method. This method, which requires the incorporation of only 10-12 microCi into the dosage form, provided reliable dissolution data after oral administration of (/sup 111/In)lactose tablets. These results were supported by in vitro experiments which demonstrated that the dissolution rate as measured by the summation peak ratio method was in close agreement with the dissolution rate of salicylic acid in a (/sup 111/In)salicylic acid tablet. The method has the advantages of using only one detector, thereby avoiding the need for complex coincidence counting systems, requiring less radioactivity, and being potentially applicable to a gamma camera imaging system.
- Research Organization:
- Univ. of Kentucky, Lexington
- OSTI ID:
- 5816139
- Journal Information:
- J. Pharm. Sci.; (United States), Vol. 10
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
INDIUM 111
SOLUBILITY
RADIOPHARMACEUTICALS
IN VIVO
LABELLED COMPOUNDS
LACTOSE
ORAL ADMINISTRATION
SALICYLIC ACID
BETA DECAY RADIOISOTOPES
CARBOHYDRATES
CARBOXYLIC ACIDS
DAYS LIVING RADIOISOTOPES
DISACCHARIDES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
HYDROXY ACIDS
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
OLIGOSACCHARIDES
ORGANIC ACIDS
ORGANIC COMPOUNDS
RADIOISOTOPES
SACCHARIDES
400702* - Radiochemistry & Nuclear Chemistry- Properties of Radioactive Materials