Effects of high dose intraperitoneal cytosine arabinoside on the radiation tolerance of the rat spinal cord

Journal Article · Sat Jul 01 00:00:00 EDT 1989 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(89)90380-5· OSTI ID:5814530

Menten, J; Landuyt, W; van der Kogel, A J; Ang, K K; van der Schueren, E

The effect of intraperitoneal high dose (9 g/kg) cytosine arabinoside (Ara-C) on the early delayed radiation response of the rat cervical spinal cord has been studied. When given 2 hrs before irradiation, systemically administered Ara-C significantly reduces the isoeffect doses for the induction of paralysis due to white matter necrosis by a factor of approximately 1.2 for both a single irradiation treatment and for a two fraction irradiation with 24 hr interval. No effect on the latency time to develop paralysis was recorded.

• Research Organization: Univ. Hospital St. Rafal, Leuven (Belgium)
• OSTI ID: 5814530
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 17:1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANTINEOPLASTIC DRUGS
RADIOSENSITIVITY EFFECTS
SPINAL CORD
DELAYED RADIATION EFFECTS
DOSE-RESPONSE RELATIONSHIPS
FRACTIONATED IRRADIATION
NECROSIS
RATS
WEIGHT
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CENTRAL NERVOUS SYSTEM
DRUGS
IRRADIATION
MAMMALS
NERVOUS SYSTEM
PATHOLOGICAL CHANGES
RADIATION EFFECTS
RODENTS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals