Effects of postnatal aluminum lactate exposure on neuromotor maturation in the rat

Journal Article · Wed Mar 01 00:00:00 EST 1989 · Bull. Environ. Contam. Toxicol.; (United States)

DOI:https://doi.org/10.1007/BF01699975· OSTI ID:5813899

Bernuzzi, V; Desor, D; Lehr, P R

In alkaline or neutral soils, aluminum is insoluble, but its solubility progressively increases with acidity, so acid precipitations have a considerable influence in mobilizing aluminum in natural waters, leading to higher alimentary ingestion of this element. In normal subjects aluminum is absorbed by the gastrointestinal tract and is excreted in urine. But even discrete renal failure may lead to Al accumulation in various tissues. Certain neurologic diseases have been related to Al intoxication. In patients undergoing chronic hemodialysis and ingesting aluminum-containing drugs, Al exposure is considered to be the causal factor for a high incidence of dialysis encephalopathy. Microcytic anemia and osteomalacia usually appeared before the neurologic symptoms. The authors have recently reported that the surviving pups of rats treated with aluminum during gestation showed a delay in their neuromotor development, as well as weight delay during the first postnatal week. This paper examines the effects of postnatal aluminum lactate exposure on mortality, weight evolution and neuromotor maturation in the rat.

• Research Organization: Universite de Metz (France)
• OSTI ID: 5813899
• Journal Information: Bull. Environ. Contam. Toxicol.; (United States), Vol. 42:3
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALUMINIUM COMPOUNDS
BIOLOGICAL EFFECTS
CENTRAL NERVOUS SYSTEM
PHYSIOLOGY
NEONATES
WEIGHT
LACTATES
MORTALITY
MUSCLES
PRENATAL EXPOSURE
RATS
REPRODUCTION
ANIMALS
CARBOXYLIC ACID SALTS
MAMMALS
NERVOUS SYSTEM
RODENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology