Distribution of /sup 109/Cd in the nervous system of rats after intravenous injection
The distribution of intravenously injected /sup 109/Cd in the nervous system was studied in rats twenty-four hr and one week after the injection. Measurements by gamma scintillation showed a high uptake of cadmium in peripheral sensory and autonomic ganglia whereas the uptake was low in the brain, cerebellum and spinal cord. The accumulation of cadmium in the sciatic nerve was significantly higher than in the brain and spinal nerve roots but lower than in ganglia. Autoradiography confirmed that there was no uptake of cadmium in the major part of the brain parenchyma, but showed an accumulation of the metal in areas outside the blood-brain barrier such as the hypophysis, meninges, choroid plexus and pineal gland. Within the peripheral nervous system, the autoradiography showed a localization of cadmium to dorsal root ganglia and, in addition, an uptake was seen in the connective tissue sheaths surrounding the sciatic nerve. The results indicate that the uptake of cadmium is correlated to regional variations in the permeability of blood vessels. The accumulation of cadmium in certain nervous structures may explain some of the neurotoxicological effects which have been demonstrated in animal experiments.
- Research Organization:
- Univ. of Uppsala, Sweden
- OSTI ID:
- 5803041
- Journal Information:
- J. Environ. Pathol., Toxicol. Oncol.; (United States), Vol. 2
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
CADMIUM 109
UPTAKE
NERVOUS SYSTEM
RADIONUCLIDE KINETICS
AUTORADIOGRAPHY
BRAIN
RATS
SCIATIC NERVE
SPINAL CORD
TISSUE DISTRIBUTION
TOXICITY
ANIMALS
BETA DECAY RADIOISOTOPES
BODY
CADMIUM ISOTOPES
CENTRAL NERVOUS SYSTEM
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
INTERMEDIATE MASS NUCLEI
ISOTOPES
MAMMALS
NERVES
NUCLEI
ORGANS
RADIOISOTOPES
RODENTS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560172* - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987)