Noninvasive measurement of lung carbon-11-serotonin extraction in man
- McMaster Univ. Medical Centre, Hamilton, Ontario (Canada)
The fraction of serotonin extracted on a single passage through the lungs is being used as an early indicator of lung endothelial damage but the existing techniques require multiple arterial blood samples. We have developed a noninvasive technique to measure lung serotonin uptake in man. We utilized the double indicator diffusion principle, a positron camera, {sup 11}C-serotonin as the substrate, and {sup 11}CO-erythrocytes as the vascular marker. From regions of interest around each lung, we recorded time-activity curves in 0.5-sec frames for 30 sec after a bolus injection of first the vascular marker {sup 11}CO-erythrocytes and 10 min later {sup 11}C-serotonin. A second uptake measurement was made after imipramine 25-35 mg was infused intravenously. In three normal volunteers, the single-pass uptake of {sup 11}C-serotonin was 63.9% +/- 3.6%. This decreased in all subjects to a mean of 53.6% +/- 1.4% after imipramine. The rate of lung washout of {sup 11}C was also significantly prolonged after imipramine. This noninvasive technique can be used to measure lung serotonin uptake to detect early changes in a variety of conditions that alter the integrity of the pulmonary endothelium.
- OSTI ID:
- 5802312
- Journal Information:
- Journal of Nuclear Medicine; (USA), Vol. 32:4; ISSN 0161-5505
- Country of Publication:
- United States
- Language:
- English
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UPTAKE
BIOLOGICAL MARKERS
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ENDOTHELIUM
ERYTHROCYTES
IMIPRAMINE
POSITRON CAMERAS
AMINES
ANIMAL TISSUES
ANTIDEPRESSANTS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
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BIOLOGICAL MATERIALS
BLOOD
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CARBON ISOTOPES
CENTRAL NERVOUS SYSTEM AGENTS
DISEASES
DRUGS
EVEN-ODD NUCLEI
GAMMA CAMERAS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
INDOLES
ISOTOPES
LIGHT NUCLEI
MATERIALS
MINUTES LIVING RADIOISOTOPES
NEUROREGULATORS
NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
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RADIOPROTECTIVE SUBSTANCES
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SYMPATHOMIMETICS
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550601* - Medicine- Unsealed Radionuclides in Diagnostics