Procedures to enhance withdrawal of xenobiotics from chickens
Egg- and meat-type chickens were fed diets containing 1 or 10 ppm of fireMaster (FF-1), a commercial mixture of polybrominated biphenyls (PBBs), predominantly 2,4,5,2',4',5'-hexabromobiphenyl (6BB-4) and 2,3,4,5,2',4',5'-heptabromobiphenyl (7BB-8). These congeners account for approximately 65 and 14%, respectively, of the total mix. In three experiments, colestipol hydrochloride, a bile acid-binding resin, and mineral oil, alone or in combination with restricted feeding, were examined as procedures to enhance the removal of the PBBs. The combination of 50% dietary restriction plus a 10% dietary concentration of colestipol or mineral oil reduced body burdens of PBBs about 70% within 21 d for chickens previously fed 10 ppm PBBs. The use of feed restriction, colestipol, or mineral oil produced only borderline effects for hastening withdrawal. Chickens not treated showed only a 3% loss of PBBs during the withdrawal period. Colestipol at 2.5% in the diet in combination with feed restriction was not consistently effective in removing body burdens of PBB from chickens previously fed 1 or 10 ppm PBBs, indicating a dose-response effect. Chickens previously fed 1 ppm eliminated up to 40% of the PBBs in 21 d without any treatment, as compared to the 3% loss occurring after feeding with 10-ppm concentrations.
- Research Organization:
- Michigan State Univ., East Lansing
- OSTI ID:
- 5801853
- Journal Information:
- J. Toxicol. Environ. Health; (United States), Vol. 2
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
BROMINATED AROMATIC HYDROCARBONS
CLEARANCE
EXCRETION
ADIPOSE TISSUE
BODY BURDEN
BODY COMPOSITION
CHICKENS
DIET
INGESTION
XENOBIOTICS
ANIMAL TISSUES
ANIMALS
AROMATICS
BIRDS
BODY
CONNECTIVE TISSUE
FOWL
HALOGENATED AROMATIC HYDROCARBONS
INTAKE
ORGANIC BROMINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
TISSUES
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)