Hepatic iron overload: Quantitative MR imaging

Journal Article · Wed May 01 00:00:00 EDT 1991 · Radiology; (USA)

DOI:https://doi.org/10.1148/radiology.179.2.2014276· OSTI ID:5801597

Gomori, J M; Horev, G; Tamary, H; Zandback, J; Kornreich, L; Zaizov, R; Freud, E; Krief, O; Ben-Meir, J; Rotem, H

Iron deposits demonstrate characteristically shortened T2 relaxation times. Several previously published studies reported poor correlation between the in vivo hepatic 1/T2 measurements made by means of midfield magnetic resonance (MR) units and the hepatic iron content of iron-overloaded patients. In this study, the authors assessed the use of in vivo 1/T2 measurements obtained by means of MR imaging at 0.5 T using short echo times (13.4 and 30 msec) and single-echo-sequences as well as computed tomographic (CT) attenuation as a measure of liver iron concentration in 10 severely iron-overloaded patients with beta-thalassemia major. The iron concentrations in surgical wedge biopsy samples of the liver, which varied between 3 and 9 mg/g of wet weight (normal, less than or equal to 0.5 mg/g), correlated well (r = .93, P less than or equal to .0001) with the preoperative in vivo hepatic 1/T2 measurements. The CT attenuation did not correlate with liver iron concentration. Quantitative MR imaging is a readily available noninvasive method for the assessment of hepatic iron concentration in iron-overloaded patients, reducing the need for needle biopsies of the liver.

• OSTI ID: 5801597
• Journal Information: Radiology; (USA), Vol. 179:2; ISSN 0033-8419
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
IRON
BIOLOGICAL ACCUMULATION
LIVER
IMAGE PROCESSING
BIOPSY
COMPUTERIZED TOMOGRAPHY
NMR IMAGING
PATIENTS
THALASSEMIA
ANEMIAS
BODY
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISEASES
ELEMENTS
GLANDS
HEMIC DISEASES
METALS
ORGANS
PROCESSING
SYMPTOMS
TOMOGRAPHY
TRANSITION ELEMENTS
550600* - Medicine
550601 - Medicine- Unsealed Radionuclides in Diagnostics