Radioprotection of intestinal stem cells and whole body radiation lethality from photons and neutrons by prostaglandins along or in combination with WR-2721. Technical report 24 Feb 86-30 Sep 89
Prostaglandins (PGs) have been shown to protect the gastrointestinal and hematopoietic cell renewal systems from some degree of radiation damage. The mechanism(s) to account for these observations are unknown. Based on preliminary evidence that PGs varied in the degree to which they afforded protection of intestinal stem cells, we studied protection by several PGs and their analogues. The most protective PGs found to date were 16,16 dm PGE2, misoprostol, a PGE1 analogues, and iloprost, a PGI2 analogue. The relative degrees of protection were 400%, 700% and 800% above control values at a dose of 13.5 137 Cs gamma radiation. These three PGs were used for subsequent studies. Iloprost is a stable PG at room temperature and was found to be protective given orally. In addition to radioprotection of the intestinal stem cells, these Pgs increased the LD50/6, LD50/30 and animal longevity through both the gastrointestinal and hematopoietic syndromes. Misoprostol protected the gut from JANUS neutrons and increased animal longevity following neutron irradiation. Although the mechanism for PG-induced radioprotection is unknown, it appears to be different compared to the widely studied amino thiol, WR-2721. Evidence to support this contention came from data showing that all these analogues were additive to the protective effect of Wr-2721.
- Research Organization:
- Rush Presbyterian Saint Luke's Medical Center, Chicago, IL (USA)
- OSTI ID:
- 5800459
- Report Number(s):
- AD-A-229889/1/XAB; CNN: DNA001-86-C-0038
- Country of Publication:
- United States
- Language:
- English
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PROSTAGLANDINS
RADIOSENSITIVITY EFFECTS
STEM CELLS
RADIATION PROTECTION
AMINES
CESIUM 137
FISSION NEUTRONS
GAMMA RADIATION
INTESTINES
PHOTONS
WHOLE-BODY IRRADIATION
ALKALI METAL ISOTOPES
ANIMAL CELLS
BARYONS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CESIUM ISOTOPES
DIGESTIVE SYSTEM
ELECTROMAGNETIC RADIATION
ELEMENTARY PARTICLES
EXTERNAL IRRADIATION
FERMIONS
GASTROINTESTINAL TRACT
HADRONS
IONIZING RADIATIONS
IRRADIATION
ISOTOPES
MASSLESS PARTICLES
NEUTRONS
NUCLEI
NUCLEONS
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
RADIATIONS
RADIOISOTOPES
SOMATIC CELLS
YEARS LIVING RADIOISOTOPES
560120* - Radiation Effects on Biochemicals
Cells
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560152 - Radiation Effects on Animals- Animals