Comparison of the inhibition of biliary excretion produced by certain inducing agents including 2,3,7,8-tetrachlorodibenzo-p-dioxin
Rats were treated with chlordecone, mirex, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), and respective solvent vehicle. Under urethane or pentobarbital anesthesia, the bile duct was cannulated and radioactive morphine, imipramine, or ouabain was given by segmented retrograde intrabiliary injection. The spectrum of inhibition of biliary excretion by chlordecone and mirex were similar in that morphine glucuronide and in part polar imipramine metabolite recoveries in bile were decreased; ouabain recovery was unaffected. TCDD was different in that it markedly decreased the recovery of ouabain. Thus, it appears that chlordecone, mirex, and TCDD inhibit the canalicular transport of the glucuronide metabolites of morphine and imipramine into bile, and TCDD affects in addition the canalicular transport of ouabain into bile.
- Research Organization:
- Veterans Administration Medical Center, Milwaukee, WI
- OSTI ID:
- 5800443
- Journal Information:
- J. Toxicol. Environ. Health; (United States), Vol. 17:4
- Country of Publication:
- United States
- Language:
- English
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Species differences in 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity and biotransformation in fish
Related Subjects
CHLORINATED AROMATIC HYDROCARBONS
TOXICITY
IMIPRAMINE
RETENTION
MORPHINE
OUABAIN
BILE
DIOXIN
INHIBITION
METABOLISM
METABOLITES
RATS
TRACER TECHNIQUES
ALKALOIDS
AMINES
ANALGESICS
ANIMALS
ANTIDEPRESSANTS
AROMATICS
BIOLOGICAL MATERIALS
BODY FLUIDS
CARBOHYDRATES
CARDIAC GLYCOSIDES
CARDIOTONICS
CARDIOVASCULAR AGENTS
CENTRAL NERVOUS SYSTEM AGENTS
CENTRAL NERVOUS SYSTEM DEPRESSANTS
DRUGS
GLYCOSIDES
HALOGENATED AROMATIC HYDROCARBONS
HETEROCYCLIC COMPOUNDS
ISOTOPE APPLICATIONS
MAMMALS
MATERIALS
NARCOTICS
OPIUM
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
PSYCHOTROPIC DRUGS
RODENTS
STROPHANTHINS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)