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Title: Enhancement of ozone-induced lung injury by exercise

Abstract

Rats were exposed for up to 3.75 h to 0.20-0.80 ppm O/sub 3/ under conditions of rest and treadmill exercise up to 30 m/min, 20% grade, to assess the importance of exposure duration, O/sub 3/ concentration, and exercise on lung tissue injury. Focal lung parenchymal lesions increased in abundance and severity in response to the three variables; however, exercise was the most important. Lesion response to exercise was greater than that predicted by a simple proportion to estimated effective dose of O/sub 3/. The results emphasize the importance of including exercise in assessment of possible adverse health effects of exposure to airborne pollutants.

Authors:
; ; ; ;
Publication Date:
Research Org.:
Univ. of California, Irvine, CA (United States)
OSTI Identifier:
5799923
Resource Type:
Journal Article
Journal Name:
J. Toxicol. Environ. Health; (United States)
Additional Journal Information:
Journal Volume: 16:6
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; LUNGS; INJURIES; OZONE; TOXICITY; AIR POLLUTION; ECOLOGICAL CONCENTRATION; EXERCISE; RATS; ANIMALS; BODY; MAMMALS; ORGANS; POLLUTION; RESPIRATORY SYSTEM; RODENTS; VERTEBRATES; 560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)

Citation Formats

Mautz, W J, McClure, T R, Reischl, P, Phalen, R F, and Crocker, T T. Enhancement of ozone-induced lung injury by exercise. United States: N. p., 1985. Web. doi:10.1080/15287398509530792.
Mautz, W J, McClure, T R, Reischl, P, Phalen, R F, & Crocker, T T. Enhancement of ozone-induced lung injury by exercise. United States. https://doi.org/10.1080/15287398509530792
Mautz, W J, McClure, T R, Reischl, P, Phalen, R F, and Crocker, T T. 1985. "Enhancement of ozone-induced lung injury by exercise". United States. https://doi.org/10.1080/15287398509530792.
@article{osti_5799923,
title = {Enhancement of ozone-induced lung injury by exercise},
author = {Mautz, W J and McClure, T R and Reischl, P and Phalen, R F and Crocker, T T},
abstractNote = {Rats were exposed for up to 3.75 h to 0.20-0.80 ppm O/sub 3/ under conditions of rest and treadmill exercise up to 30 m/min, 20% grade, to assess the importance of exposure duration, O/sub 3/ concentration, and exercise on lung tissue injury. Focal lung parenchymal lesions increased in abundance and severity in response to the three variables; however, exercise was the most important. Lesion response to exercise was greater than that predicted by a simple proportion to estimated effective dose of O/sub 3/. The results emphasize the importance of including exercise in assessment of possible adverse health effects of exposure to airborne pollutants.},
doi = {10.1080/15287398509530792},
url = {https://www.osti.gov/biblio/5799923}, journal = {J. Toxicol. Environ. Health; (United States)},
number = ,
volume = 16:6,
place = {United States},
year = {Tue Jan 01 00:00:00 EST 1985},
month = {Tue Jan 01 00:00:00 EST 1985}
}