The molecular and developmental biology of keratins
Keratins make up the intermediate filaments found in almost all epithelia from fish to mammals, and are the products of multigene families. The great diversity in the form and function of epithelia and the tissue-specific expression of the keratins with their ''pairing rules'' makes the study of epithelial differentiation an excellent paradigm for studying the development regulation of gene expression. This book discusses the following contents: Introduction; The Human Keratin Genes and Their Differential Expression; Expression and Modification of keratins during Terminal Differentiation of Mammalian Epidermis; The Experimental Manipulation of Keratin Expression and Organization in Epithelial Cells and Somatic Cells Hybrids; Patterns of Keratin Expression Define Distinct Pathways of Epithelial Development and Differentiation; Developmental Expression of Human Epidermal Keratins and Filaggrin; Cytokeratins in Oocytes and Preimplantation Embryos of the Mouse; Role of Epidermal Growth Factor in Embryonic Development; Regulation of Keratin Gene Expression during Differentiation of Epidermal and Vaginal Epithelial Cells; Abnormal Development in the Skin of the Pupoid Fetus (pf/pf) Mutant Mouse; Abnormal Keratinization, Recovery of a Normal Phenotype, and Relationship of the Repeated Epilation (Er) Mutant Mouse. Expression of B-Keratin Genes during Development of Avian Skin Appendages; Concluding Remarks and Future Directions. Each chapter includes references and index.
- OSTI ID:
- 5786707
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
KERATIN
BIOCHEMISTRY
GENE REGULATION
GENES
MOLECULAR BIOLOGY
BIOLOGICAL PATHWAYS
CELL DIFFERENTIATION
EMBRYOS
EPIDERMIS
FEMALE GENITALS
GROWTH
GROWTH FACTORS
MICE
MUTATIONS
REVIEWS
ANIMAL TISSUES
ANIMALS
BODY
CHEMISTRY
DOCUMENT TYPES
EPITHELIUM
MAMMALS
MITOGENS
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RODENTS
SCLEROPROTEINS
SKIN
TISSUES
VERTEBRATES
550200* - Biochemistry