Regulation of natural killer activity of lymphocytes from normal subjects and patients with chronic lymphatic leukemia by interaction between T and non-T cells

Journal Article · Sat Aug 01 00:00:00 EDT 1987 · Bull. Exp. Biol. Med. (Engl. Transl.); (United States)

DOI:https://doi.org/10.1007/BF00840562· OSTI ID:5785280

Khonina, N A; Shubinskii, G Z; Lozovoi, V P

The authors study the effect of culture of human cells on functional activity of natural killer cells and investigate the possible mechanisms of regulation of natural killer activity by acting on cytodifferentiation of lymphocytes in normal subjects and in patients with the B-cell variant of chromic lymphatic leukemia. To estimate natural killer cell function, a membranotoxic test was carried out, using cells of the transplantable line K-562, labeled with /sup 3/H-uridine as the targets.

• Research Organization: Institute of Clinical Immunology, Novosibirsk, USSR
• OSTI ID: 5785280
• Journal Information: Bull. Exp. Biol. Med. (Engl. Transl.); (United States), Vol. 103:3; Other Information: Translated from Byulleten Ehksperimental'noj Biologii i Meditsiny; 103: No. 3, 321-323(Mar 1987)
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
LYMPHOCYTES
BIOLOGICAL FUNCTIONS
CELL DIFFERENTIATION
RADIOIMMUNOASSAY
PATIENTS
LEUKEMIA
TUMOR CELLS
CELL KILLING
CELL CULTURES
CYTOCHEMISTRY
LABELLING
MAN
RADIOACTIVITY
TRITIUM COMPOUNDS
URIDINE
ANIMAL CELLS
ANIMALS
AZINES
BIOCHEMISTRY
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CHEMISTRY
CONNECTIVE TISSUE CELLS
DISEASES
FUNCTIONS
HEMIC DISEASES
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
IMMUNOASSAY
IMMUNOLOGY
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LEUKOCYTES
MAMMALS
MATERIALS
NEOPLASMS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PRIMATES
PYRIMIDINES
RADIOASSAY
RADIOIMMUNOLOGY
RIBOSIDES
SOMATIC CELLS
TRACER TECHNIQUES
URACILS
VERTEBRATES
550301* - Cytology- Tracer Techniques