Kinetics of reparative DNA replication induced in CBA and C57BL/6 mouse spleen cells by urethane and influenza virus
The authors investigated the reparative replication of DNA, induced by urethane and influenza virus in C57BL/6 and CBA mice which have marked differences in tumor formation. Reparative DNA replication, induced by urethane and influenza virus was investigated by a liquid scintillation method based on measuring incorporation of /sup 3/H-thymidine into the total mass of mouse spleen cells, when replicative DNA synthesis was inhibited by hydroxyurea. The intensity of reparative DNA replication was judged from the value of the stimulation index which is the ratio of the radioactivity in the spleen cells of the experimental animals to the corresponding parameters in cells of intact animals. The phenomenon of the stimulating and inhibitory effects of influenza virus on reparative DNA replication in cells depending on their genotype and sensitivity to virus is established.
- Research Organization:
- L. V. Gromashevskii Kiev Research Institute of Epidemiology and Infectious Diseases, USSR
- OSTI ID:
- 5783255
- Journal Information:
- Bull. Exp. Biol. Med. (Engl. Transl.); (United States), Vol. 101:4; Other Information: Translated from Byulleten' Ehksperimental'noj Biologii i Meditsiny; 101: No. 4, 426-428(Apr 1986)
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
INFLUENZA VIRUSES
BIOLOGICAL EFFECTS
MICE
CARCINOGENESIS
SPLEEN CELLS
BIOLOGICAL REPAIR
DNA REPLICATION
TRACER TECHNIQUES
URETHANE
BIOCHEMICAL REACTION KINETICS
INHIBITION
LYMPHOCYTES
RADIOACTIVITY
SCINTILLATION COUNTING
STIMULATION
THYMIDINE
TRITIUM COMPOUNDS
TUMOR CELLS
UPTAKE
ANIMAL CELLS
ANIMALS
AZINES
BIOLOGICAL MATERIALS
BIOLOGICAL RECOVERY
BLOOD
BLOOD CELLS
BODY FLUIDS
CARBAMATES
CARBONIC ACID DERIVATIVES
CARBOXYLIC ACID SALTS
CONNECTIVE TISSUE CELLS
COUNTING TECHNIQUES
HETEROCYCLIC COMPOUNDS
ISOTOPE APPLICATIONS
KINETICS
LABELLED COMPOUNDS
LEUKOCYTES
MAMMALS
MATERIALS
MICROORGANISMS
NUCLEIC ACID REPLICATION
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PARASITES
PATHOGENESIS
PYRIMIDINES
REACTION KINETICS
RECOVERY
REPAIR
RIBOSIDES
RODENTS
SOMATIC CELLS
VERTEBRATES
VIRUSES
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