Effect of trihydroxyoctadecadienoic acids on blood levels of prostaglandins E/sub 2/ and F/sub 2. cap alpha. / and of 5-hydroxyeicosatetraenoic acid in rats with alloxan diabetes
The effect of the trihydroxyoctadecadienoic acids (THODA) fraction on blood levels of some eicosanoids and, in particular, of prostaglandins E/sub 2/ and F/sub 2..cap alpha../(PGE/sub 2/ and PGF/sub 2..cap alpha../), and 5-hydroxyeicosatetraenoic acid (5-HETE) in rats with alloxan diabetes was studied. Concentrations of PGE/sub 2/, PGF/sub 2..cap alpha../, and 5-HETE in peripheral blood plasma were determined by radioimmunoassay. To assess the loss of substances during extraction and chromatography, /sup 3/H/sub 8/-PGE/sub 2/, /sup 3/H/sub 8/-PGF/sub 2..cap alpha.., and /sup 3/H/sub 8/-5-HETE were used. Plasma PGE/sub 2/, PGF/sub 2..cap alpha../, and 5-HETE levels in albino rats with alloxan diabetes and after injection of THODA are shown.
- Research Organization:
- Institute of Biochemistry, Erevan, USSR
- OSTI ID:
- 5779676
- Journal Information:
- Bull. Exp. Biol. Med. (Engl. Transl.); (United States), Vol. 101:4; Other Information: Translated from Byulleten' Ehksperimental'noj Biologii i Meditsiny; 101: No. 4, 418-419(Apr 1986)
- Country of Publication:
- United States
- Language:
- English
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BLOOD PLASMA
BIOCHEMISTRY
CARBOXYLIC ACIDS
BIOLOGICAL EFFECTS
PROSTAGLANDINS
RADIOIMMUNOASSAY
RATS
DIABETES MELLITUS
ALLOXAN
DECANOIC ACID
EICOSANOIC ACID
GLUCOSE
INTRAPERITONEAL INJECTION
QUANTITY RATIO
SCINTILLATION COUNTING
TRITIUM COMPOUNDS
ALDEHYDES
ANIMALS
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BIOLOGICAL MATERIALS
BLOOD
BODY FLUIDS
CARBOHYDRATES
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COUNTING TECHNIQUES
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ENDOCRINE DISEASES
HETEROCYCLIC COMPOUNDS
HEXOSES
IMMUNOASSAY
IMMUNOLOGY
INJECTION
INTAKE
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MATERIALS
METABOLIC DISEASES
MONOCARBOXYLIC ACIDS
MONOSACCHARIDES
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
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VERTEBRATES
550901* - Pathology- Tracer Techniques
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