Diagnostic value of bone marrow imaging with /sup 111/indium-transferrin and /sup 99m/technetium-colloids in myelofibrosis
/sup 111/Indium--transferrin (/sup 111/In) and /sup 99m/Technetium-colloids (/sup 99m/Tc) bone marrow imaging of 55 myelofibrosis (MF) cases has been compared with clinical, histological, and iron-kinetics data. The best correlations are seen between the splenic uptake of /sup 111/In with the spleen/sacrum ratio of /sup 59/Fe at the first hour and also with the splenic erythropoiesis histologically assessed in ten splenectomized patients. Moreover, sacrum uptake of /sup 111/In, when compared with sacrum uptake of /sup 59/Fe and with hematopoietic cellularity of the bone marrow reflects faithfully the hematopoietic cell content of the marrow. Thus, /sup 111/In bone marrow imaging provides a noninvasive and useful tool for the diagnosis of myeloid metaplasia in MF. Ferrokinetic studies still appreciate with better insight the amount of ineffective erythropoiesis or hemolysis and remain therefore of great value when splenectomy is discussed.
- Research Organization:
- Hopital Saint-Louis, Paris, France
- OSTI ID:
- 5779088
- Journal Information:
- Am. J. Hematol.; (United States), Vol. 18:3
- Country of Publication:
- United States
- Language:
- English
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550601* - Medicine- Unsealed Radionuclides in Diagnostics