Radiation dosimetry of iodine-123 HEAT, an alpha-1 receptor imaging agent

Journal Article · Sun Nov 01 00:00:00 EST 1987 · J. Nucl. Med.; (United States)

OSTI ID:5777762

Thomas, K D; Greer, D M; Couch, M W; Williams, C M

Biologic distribution data in the rat were obtained for the alpha-1 adrenoceptor imaging agent (+/-) 2-(beta-(iodo-4-hydroxyphenyl)ethylaminomethyl)tetralone (HEAT) labeled with (/sup 123/I). The major excretory routes were through the liver (67%) and the kidney (33%). Internal radiation absorbed dose estimates to nine source organs, total body, the GI tract, gonads, and red bone marrow were calculated for the human using the physical decay data for (/sup 123/I). The critical organ was found to be the lower large intestine, receiving 1.1 rad per mCi of (/sup 123/I)HEAT administered. The total-body dose was found to be 58 mrad per mCi.

• Research Organization: Veterans Administration Medical Center, Gainesville, FL
• OSTI ID: 5777762
• Journal Information: J. Nucl. Med.; (United States), Vol. 28:11
• Country of Publication: United States
• Language: English

Related Subjects

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RADIONUCLIDE KINETICS
RADIOPHARMACEUTICALS
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