Evidence for increased peroxidative activity in muscles from streptozotocin-diabetic rats
The ability of cardiac and skeletal muscles from diabetic rats to metabolize superoxide and hydrogen peroxide was determined by the activities of superoxide dismutase (SOD) and catalase, respectively. Male and female Sprague-Dawley rats, 43 days old, were made diabetic with a single intravenous injection of streptozotocin (70 mg/kg body weight). On the 80th day after injection the blood glucose concentration of these rats was increased fourfold, and the plasma insulin concentration was decreased four- to fivefold compared to controls. Body weights of male diabetic rats were 61% and those of female diabetic rats were 66% of their ad libitum-fed controls. The seven different skeletal muscles examined weighed less in the diabetic rats than in controls of the same age and body weight. Comparison to the body weight controls allowed the distinction of specific effects due to lack of insulin from effects due to retardation in muscle growth. Increased catalase activity in all muscles examined from diabetic rats (plantaris, gastrocnemius, and heart) suggested a response in catalase activity similar to that of starved rats. SOD activity was not altered in the diabetic rat skeletal muscles and erythrocytes, but was somewhat decreased in the heart.
- Research Organization:
- Univ. of Minnesota, St. Paul
- OSTI ID:
- 5774790
- Journal Information:
- Proc. Soc. Exp. Biol. Med.; (United States), Vol. 176:1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
CATALASE
ENZYME ACTIVITY
HYDROGEN PEROXIDE
METABOLISM
MUSCLES
PHYSIOLOGY
SUPEROXIDE DISMUTASE
SUPEROXIDE RADICALS
ANTIBIOTICS
DIABETES MELLITUS
EXPERIMENTAL DATA
GLUCOSE
HEART
INSULIN
INTRAVENOUS INJECTION
RATS
WEIGHT
ALDEHYDES
ANIMALS
ANTI-INFECTIVE AGENTS
BODY
CARBOHYDRATES
CARBOXYLIC ACIDS
CARDIOVASCULAR SYSTEM
DATA
DISEASES
DRUGS
ENDOCRINE DISEASES
ENZYMES
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HEXOSES
HORMONES
HYDROGEN COMPOUNDS
INFORMATION
INJECTION
INTAKE
MAMMALS
METABOLIC DISEASES
MONOSACCHARIDES
NUMERICAL DATA
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXIDOREDUCTASES
OXYGEN COMPOUNDS
PEPTIDE HORMONES
PEROXIDASES
PEROXIDES
PORPHYRINS
RADICALS
RODENTS
SACCHARIDES
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)