Acute effects of cigarette smoke exposure on experimental skin flaps
Random vascular patterned caudally based McFarlane-type skin flaps were elevated in groups of Fischer 344 rats. Groups of rats were then acutely exposed on an intermittent basis to smoke generated from well-characterized research filter cigarettes. Previously developed smoke inhalation exposure protocols were employed using a Maddox-ORNL inhalation exposure system. Rats that continued smoke exposure following surgery showed a significantly greater mean percent area of flap necrosis compared with sham-exposed groups or control groups not exposed. The possible pathogenesis of this observation as well as considerations and correlations with chronic human smokers are discussed. Increased risks of flap necrosis by smoking in the perioperative period are suggested by this study.
- Research Organization:
- Univ. of Illinois Medical Center, Chicago
- DOE Contract Number:
- W-7405-ENG-26
- OSTI ID:
- 5766539
- Journal Information:
- Plast. Reconstr. Surg.; (United States), Vol. 75:4
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
SKIN
NECROSIS
TOBACCO SMOKES
TOXICITY
BIOLOGICAL MODELS
EXPERIMENTAL DATA
INHALATION
PATHOGENESIS
RATS
RISK ASSESSMENT
SURGERY
AEROSOLS
ANIMALS
BODY
COLLOIDS
DATA
DISPERSIONS
INFORMATION
INTAKE
MAMMALS
MEDICINE
NUMERICAL DATA
ORGANS
PATHOLOGICAL CHANGES
RESIDUES
RODENTS
SMOKES
SOLS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
550900 - Pathology