Hyperfractionation decreases the deleterious effects of conventional radiation fractionation on vertebral growth in animals

Journal Article · Thu Jun 15 00:00:00 EDT 1989 · Cancer (Philadelphia); (United States)

DOI:https://doi.org/10.1002/1097-0142(19890615)63:12<2452::AID-CNCR2820631215>3.0.CO;2-3· OSTI ID:5765339

Hartsell, W F; Hanson, W R; Conterato, D J; Hendrickson, F R

Craniospinal axis irradiation in the treatment of pediatric tumors is associated with serious long-term sequelae including decreased bone growth (short sitting stature). In this study, an animal model was used to determine the effects of smaller incremental doses of radiation on bone growth. Sprague-Dawley weanling rats were given 25 Gy to the spine in 8 to 9 days, with fraction sizes ranging from 1.0 to 1.8 Gy. The animals receiving smaller doses per fraction (1.0 or 1.25 Gy) showed significantly more growth of the vertebral bodies in the treated fields than animals given larger incremental doses (1.5 or 1.8 Gy). These findings indicate a protective effect on bone growth for hyperfractionated irradiation of vertebral bodies.

• Research Organization: Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL (USA)
• OSTI ID: 5765339
• Journal Information: Cancer (Philadelphia); (United States), Vol. 63:12
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
NEOPLASMS
RADIOTHERAPY
SIDE EFFECTS
SKELETON
BIOLOGICAL RADIATION EFFECTS
VERTEBRAE
ANIMAL GROWTH
BIOLOGICAL MODELS
CESIUM ISOTOPES
CHILDREN
FRACTIONATED IRRADIATION
RADIATION DOSES
RATS
WEIGHT
AGE GROUPS
ALKALI METAL ISOTOPES
ANIMALS
BIOLOGICAL EFFECTS
BODY
DISEASES
DOSES
GROWTH
IRRADIATION
ISOTOPES
MAMMALS
MEDICINE
NUCLEAR MEDICINE
ORGANS
RADIATION EFFECTS
RADIOLOGY
RODENTS
THERAPY
VERTEBRATES
560151* - Radiation Effects on Animals- Man