Improved radioimaging and tumor localization with monoclonal F(ab')2

Journal Article · Fri Apr 01 00:00:00 EST 1983 · J. Nucl. Med.; (United States)

OSTI ID:5764410

Wahl, R L; Parker, C W; Philpott, G W

Monoclonal anti-tumor antibodies have great promise for radioimmunodetection and localization of tumors. Fab and F(ab')2 fragments, which lack the Fc fragment of antibody (Ab), are cleared more rapidly from the circulation and may have less nonspecific tissue binding than intact Ab. In radioimaging studies using a murine monoclonal antibody to carcinoembryonic antigen in a human colon carcinoma xenografted into hamsters, F(ab')2 fragments were shown superior to Fab fragments and intact antibody for scintiscanning. In double-label experiments with anti-CEA antibody and control monoclonal IgG, F(ab')2 fragments were found to give better and more rapid specific tumor localization than intact antibody or Fab fragments. F(ab')2 fragments offer significant promise for tumor imaging and possibly therapy.

• Research Organization: Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri
• OSTI ID: 5764410
• Journal Information: J. Nucl. Med.; (United States), Vol. 24:4
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
LARGE INTESTINE
SCINTISCANNING
MONOCLONAL ANTIBODIES
DIAGNOSTIC USES
CARCINOEMBRYONIC ANTIGEN
CARCINOMAS
IMAGES
NEOPLASMS
ANTIBODIES
ANTIGENS
BODY
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISEASES
GASTROINTESTINAL TRACT
INTESTINES
ORGANS
RADIOISOTOPE SCANNING
USES
550601* - Medicine- Unsealed Radionuclides in Diagnostics