Alterations of the (/sup 59/Fe)ferric citrate biodistribution in hyperferremic mice after the administration of pyrophosphate and desferrioxamine
One of the most efficient anions in enhancing the ability of desferrioxamine (DFO) to remove iron from transferrin in vitro has been shown to be pyrophosphate (PYP). To evaluate the in vivo effect of PYP in hyperferremic mice, the biodistribution of (/sup 59/Fe)ferric citrate was studied after the i.p. administration of: 1) only saline in the control animals; 2) an aqueous solution of tetrasodium diphosphate; 3) desferral; and 4) PYP + DFO. The radioactivity in each organ, blood, urine and feces was measured and referred to as percentage of the injected dose. PYP administered alone acted as a weaker chelator of iron than DFO. The combined administration of DFO and PYP contributed more than DFO or PYP separately, to the increase of urinary excretion of 59Fe and to the significant decrease of the radioiron concentration in liver. The above induced changes are not, however, the additive result of the separate effect of DFO and PYP. That observation would suggest that DFO + PYP combined in a unique treatment, interact with iron through a common reaction pathway and that PYP plays in vivo a synergistic role in that interaction. The kind of iron with which DFO + PYP interacts is then suggested to be the transferrin-bound iron located in extracellular spaces of tissues.
- Research Organization:
- Nuclear Research Center, Attiki, Greece
- OSTI ID:
- 5763133
- Journal Information:
- J. Pharmacol. Exp. Ther.; (United States), Vol. 224:2
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
DEFEROXAMINE
BIOLOGICAL EFFECTS
IRON 59
TISSUE DISTRIBUTION
IRON COMPOUNDS
PYROPHOSPHATES
BLOOD
CHELATING AGENTS
CITRATES
FECES
MICE
TRANSFERRIN
URINE
AMINES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY FLUIDS
CARBOXYLIC ACID SALTS
DAYS LIVING RADIOISOTOPES
DISTRIBUTION
EVEN-ODD NUCLEI
GLOBULINS
GLOBULINS-BETA
INTERMEDIATE MASS NUCLEI
IRON ISOTOPES
ISOTOPES
MAMMALS
MATERIALS
METALLOPROTEINS
NUCLEI
ORGANIC COMPOUNDS
OXYGEN COMPOUNDS
PHOSPHORUS COMPOUNDS
PROTEINS
RADIOISOTOPES
RODENTS
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES
WASTES
560172* - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987)