Scanning and transmission electron microscopy of the damage to small intestinal mucosa following X irradiation or hyperthermia

Carr, K E; Hume, S P; Marigold, J C; Michalowski, A

Title: Scanning and transmission electron microscopy of the damage to small intestinal mucosa following X irradiation or hyperthermia

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Abstract

Scanning and transmission electron microscopy (S.E.M. and T.E.M.) and resin histology have been used to investigate the effects on mouse small intestinal villi of heating at 43 degrees C for 20 minutes and of irradiation with 10 Gy X-rays. Damage after irradiation included conical villi and giant cells. Damage after heating included the production of conical and rudimentary villi and the stacking of enterocytes. Individual cells showed signs of abnormalities in their cell membranes, nuclei and cytoplasmic components. The differences in the response after irradiation and hyperthermia are linked to the fact that heating has a primary effect on villous structure, whereas irradiation mainly affects the proliferative pool of crypt cells.

Authors:: Carr, K E; Hume, S P; Marigold, J C; Michalowski, A

Publication Date:: Fri Jan 01 00:00:00 EST 1982

Research Org.:: Anatomy Department, University of Glasgow

OSTI Identifier:: 5762201

Resource Type:: Journal Article

Journal Name:: Scanning Electron Microsc.; (United States)

Additional Journal Information:: Journal Name: Scanning Electron Microsc.; (United States)

Country of Publication:: United States

Language:: English

Subject:: 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; MUCOUS MEMBRANES; BIOLOGICAL RADIATION EFFECTS; SMALL INTESTINE; HYPERTHERMIA; MICE; TEMPERATURE EFFECTS; ULTRASTRUCTURAL CHANGES; X RADIATION; ANIMALS; BIOLOGICAL EFFECTS; BODY; BODY TEMPERATURE; DIGESTIVE SYSTEM; ELECTROMAGNETIC RADIATION; GASTROINTESTINAL TRACT; INTESTINES; IONIZING RADIATIONS; MAMMALS; MEMBRANES; MORPHOLOGICAL CHANGES; ORGANS; RADIATION EFFECTS; RADIATIONS; RODENTS; VERTEBRATES; 560152* - Radiation Effects on Animals- Animals

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                    Carr, K E, Hume, S P, Marigold, J C, and Michalowski, A. Scanning and transmission electron microscopy of the damage to small intestinal mucosa following X irradiation or hyperthermia.  United States: N. p., 1982. 
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                    Carr, K E, Hume, S P, Marigold, J C, & Michalowski, A. Scanning and transmission electron microscopy of the damage to small intestinal mucosa following X irradiation or hyperthermia.  United States.

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                    Carr, K E, Hume, S P, Marigold, J C, and Michalowski, A. 1982.  
        "Scanning and transmission electron microscopy of the damage to small intestinal mucosa following X irradiation or hyperthermia".  United States.

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@article{osti_5762201,

  title        = {Scanning and transmission electron microscopy of the damage to small intestinal mucosa following X irradiation or hyperthermia},

  author       = {Carr, K E and Hume, S P and Marigold, J C and Michalowski, A},

  abstractNote = {Scanning and transmission electron microscopy (S.E.M. and T.E.M.) and resin histology have been used to investigate the effects on mouse small intestinal villi of heating at 43 degrees C for 20 minutes and of irradiation with 10 Gy X-rays. Damage after irradiation included conical villi and giant cells. Damage after heating included the production of conical and rudimentary villi and the stacking of enterocytes. Individual cells showed signs of abnormalities in their cell membranes, nuclei and cytoplasmic components. The differences in the response after irradiation and hyperthermia are linked to the fact that heating has a primary effect on villous structure, whereas irradiation mainly affects the proliferative pool of crypt cells.},

  doi          = {},

  url          = {https://www.osti.gov/biblio/5762201},
  journal      = {Scanning Electron Microsc.; (United States)},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {Fri Jan 01 00:00:00 EST 1982},

  month        = {Fri Jan 01 00:00:00 EST 1982}

}

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