Biologic indicators of cadmium nephrotoxicity in persons with low-level cadmium exposure

Journal Article · Thu Mar 01 00:00:00 EST 1984 · Environ. Health Perspect.; (United States)

DOI:https://doi.org/10.1289/ehp.8454163· OSTI ID:5761775

Nogawa, K

The relationship between abnormal urinary findings and renal function was investigated for 33 Itai-Itai patients, 17 suspected patients, 235 subjects exposed to Cd and 41 subjects not exposed to Cd pollution. High correlation coefficients were observed between urinary findings and renal function in advanced cases of chronic cadmium poisoning, and multiple correlation coefficients between them are as high as 0.73 to 0.86. ..beta../sub 2/-microglobulin in urine also correlated closely with renal function and age in slight to moderate cases of cadmium poisoning. It is concluded that urinary findings such as proteinuria, glucosuria and low molecular weight proteinuria are good indicators of renal dysfunction in moderate to severe cases of cadmium poisoning. In slight to moderate cases ..beta../sub 2/-microglobulin in urine has a close relation with renal dysfunction. 7 references, 2 figures, 8 tables.

• Research Organization: Kanazawa Medical Univ., Japan
• OSTI ID: 5761775
• Journal Information: Environ. Health Perspect.; (United States), Vol. 54
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CADMIUM
TOXICITY
KIDNEYS
INJURIES
AGE DEPENDENCE
BIOLOGICAL FUNCTIONS
BIOLOGICAL INDICATORS
CHRONIC EXPOSURE
PATIENTS
PROTEINS
STATISTICAL DATA
URINE
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY
BODY FLUIDS
DATA
ELEMENTS
FUNCTIONS
INFORMATION
MATERIALS
METALS
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANS
WASTES
560306* - Chemicals Metabolism & Toxicology- Man- (-1987)