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Title: Human papillomavirus types 16 and 18 in adenocarcinoma of the uterine cervix

Abstract

Many reports have shown a link between human papillomavirus (HPV) and cervical squamous neoplasia. However, the association of HPV with cervical adenocarcinoma has been studied less extensively. The authors evaluated the presence of HPV-DNA in 106 patients with adenocarcinoma of the uterine cervix by in situ hybridization, using {sup 35}S-labeled probes for HPV 16 DNA and HPV 18 DNA. The overall prevalence of HPV-DNA was 18% (19 of 106). HPV 16 was present in 2 (2%) cases, HPV 18 was observed in 15 (14%) cases, and both HPV 16 and HPV 18 were found in 2 (2%) cases. There was a correlation between HPV-DNA positivity and tumor stage (P less than 0.01) and tumor size (P less than 0.05), but there was no relationship between HPV-DNA positivity and tumor differentiation, proliferation (S-phase fraction), ploidy, lymph node metastases, or five-year survival rate. These results suggest that HPV 18 DNA is associated with cervical adenocarcinoma but the presence of HPV 18 has no influence on overall survival.

Authors:
; ; ; ; ;  [1]
  1. Helsinki Univ. Central Hospital, (Finland)
Publication Date:
OSTI Identifier:
5761518
Resource Type:
Journal Article
Journal Name:
American Journal of Clinical Pathology; (USA)
Additional Journal Information:
Journal Volume: 95:5; Journal ID: ISSN 0002-9173
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; TUMOR CELLS; CELL PROLIFERATION; UTERUS; CARCINOMAS; VIRUSES; DNA; CELL FLOW SYSTEMS; DNA HYBRIDIZATION; MAN; PATIENTS; SULFUR 35; SURVIVAL CURVES; TRACER TECHNIQUES; ANIMAL CELLS; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; DAYS LIVING RADIOISOTOPES; DISEASES; EVEN-ODD NUCLEI; FEMALE GENITALS; HYBRIDIZATION; ISOTOPE APPLICATIONS; ISOTOPES; LIGHT NUCLEI; MAMMALS; MICROORGANISMS; NEOPLASMS; NUCLEI; NUCLEIC ACIDS; ORGANIC COMPOUNDS; ORGANS; PARASITES; PRIMATES; RADIOISOTOPES; SULFUR ISOTOPES; VERTEBRATES; 550901* - Pathology- Tracer Techniques

Citation Formats

Leminen, A, Paavonen, J, Vesterinen, E, Wahlstroem, T R, Rantala, I, and Lehtinen, M. Human papillomavirus types 16 and 18 in adenocarcinoma of the uterine cervix. United States: N. p., 1991. Web. doi:10.1093/ajcp/95.5.647.
Leminen, A, Paavonen, J, Vesterinen, E, Wahlstroem, T R, Rantala, I, & Lehtinen, M. Human papillomavirus types 16 and 18 in adenocarcinoma of the uterine cervix. United States. https://doi.org/10.1093/ajcp/95.5.647
Leminen, A, Paavonen, J, Vesterinen, E, Wahlstroem, T R, Rantala, I, and Lehtinen, M. 1991. "Human papillomavirus types 16 and 18 in adenocarcinoma of the uterine cervix". United States. https://doi.org/10.1093/ajcp/95.5.647.
@article{osti_5761518,
title = {Human papillomavirus types 16 and 18 in adenocarcinoma of the uterine cervix},
author = {Leminen, A and Paavonen, J and Vesterinen, E and Wahlstroem, T R and Rantala, I and Lehtinen, M},
abstractNote = {Many reports have shown a link between human papillomavirus (HPV) and cervical squamous neoplasia. However, the association of HPV with cervical adenocarcinoma has been studied less extensively. The authors evaluated the presence of HPV-DNA in 106 patients with adenocarcinoma of the uterine cervix by in situ hybridization, using {sup 35}S-labeled probes for HPV 16 DNA and HPV 18 DNA. The overall prevalence of HPV-DNA was 18% (19 of 106). HPV 16 was present in 2 (2%) cases, HPV 18 was observed in 15 (14%) cases, and both HPV 16 and HPV 18 were found in 2 (2%) cases. There was a correlation between HPV-DNA positivity and tumor stage (P less than 0.01) and tumor size (P less than 0.05), but there was no relationship between HPV-DNA positivity and tumor differentiation, proliferation (S-phase fraction), ploidy, lymph node metastases, or five-year survival rate. These results suggest that HPV 18 DNA is associated with cervical adenocarcinoma but the presence of HPV 18 has no influence on overall survival.},
doi = {10.1093/ajcp/95.5.647},
url = {https://www.osti.gov/biblio/5761518}, journal = {American Journal of Clinical Pathology; (USA)},
issn = {0002-9173},
number = ,
volume = 95:5,
place = {United States},
year = {Wed May 01 00:00:00 EDT 1991},
month = {Wed May 01 00:00:00 EDT 1991}
}