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Title: A morphological study of radiation nephropathy in the pig

Abstract

Both kidneys of mature pigs received a single dose of 9.8 Gy {sup 60}Co gamma rays. Pigs were killed between 2 and 24 weeks after irradiation and the kidneys examined histologically. Glomerular and tubular changes were observed within 2 weeks of irradiation. Neutrophils and other leukocytes were seen within glomerular capillary loops; mesangial matrix and cell number increased. A progressive increase in thickening of the basement membrane and a decrease in capillary lumina were then noted. Basement membrane duplication occurred within 12 weeks. By 24 weeks these lesions had increased in severity, sclerotic endstage glomeruli, predominantly subcapsular or juxtamedullary, being evident. Tubular lesions initially consisted of focal areas of tubular atrophy in the juxtamedullary region. By 6 weeks subcapsular foci of tubular degeneration, regeneration, and necrosis were found; these appeared to resolve 12 weeks after irradiation. At later times the severity of the tubular lesions varied between pigs, with some exhibiting interstitial fibrosis involving a complete band of subcapsular tissue, while others showed relatively mild changes. There was no apparent change in the vasculature. These findings indicate that (a) there is no one target or dose-limiting cell, and (b) the vasculature does not play a primary role in the developmentmore » of radiation nephropathy.« less

Authors:
; ; ; ; ; ;  [1]
  1. Churchill Hospital, Headington, (United Kingdom)
Publication Date:
OSTI Identifier:
5760317
Resource Type:
Journal Article
Journal Name:
Radiation Research; (USA)
Additional Journal Information:
Journal Volume: 126:3; Journal ID: ISSN 0033-7587
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; KIDNEYS; BIOLOGICAL RADIATION EFFECTS; BLOOD VESSELS; COBALT 60; GAMMA RADIATION; LEUKOCYTES; MORPHOLOGICAL CHANGES; NEUTROPHILS; SWINE; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY; BODY FLUIDS; CARDIOVASCULAR SYSTEM; COBALT ISOTOPES; DOMESTIC ANIMALS; ELECTROMAGNETIC RADIATION; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; IONIZING RADIATIONS; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MAMMALS; MATERIALS; MINUTES LIVING RADIOISOTOPES; NUCLEI; ODD-ODD NUCLEI; ORGANS; RADIATION EFFECTS; RADIATIONS; RADIOISOTOPES; VERTEBRATES; YEARS LIVING RADIOISOT; 560152* - Radiation Effects on Animals- Animals

Citation Formats

Robbins, M E, Wooldridge, M J, Jaenke, R S, Whitehouse, E, Golding, S J, Rezvani, M, and Hopewell, J W. A morphological study of radiation nephropathy in the pig. United States: N. p., 1991. Web. doi:10.2307/3577921.
Robbins, M E, Wooldridge, M J, Jaenke, R S, Whitehouse, E, Golding, S J, Rezvani, M, & Hopewell, J W. A morphological study of radiation nephropathy in the pig. United States. https://doi.org/10.2307/3577921
Robbins, M E, Wooldridge, M J, Jaenke, R S, Whitehouse, E, Golding, S J, Rezvani, M, and Hopewell, J W. 1991. "A morphological study of radiation nephropathy in the pig". United States. https://doi.org/10.2307/3577921.
@article{osti_5760317,
title = {A morphological study of radiation nephropathy in the pig},
author = {Robbins, M E and Wooldridge, M J and Jaenke, R S and Whitehouse, E and Golding, S J and Rezvani, M and Hopewell, J W},
abstractNote = {Both kidneys of mature pigs received a single dose of 9.8 Gy {sup 60}Co gamma rays. Pigs were killed between 2 and 24 weeks after irradiation and the kidneys examined histologically. Glomerular and tubular changes were observed within 2 weeks of irradiation. Neutrophils and other leukocytes were seen within glomerular capillary loops; mesangial matrix and cell number increased. A progressive increase in thickening of the basement membrane and a decrease in capillary lumina were then noted. Basement membrane duplication occurred within 12 weeks. By 24 weeks these lesions had increased in severity, sclerotic endstage glomeruli, predominantly subcapsular or juxtamedullary, being evident. Tubular lesions initially consisted of focal areas of tubular atrophy in the juxtamedullary region. By 6 weeks subcapsular foci of tubular degeneration, regeneration, and necrosis were found; these appeared to resolve 12 weeks after irradiation. At later times the severity of the tubular lesions varied between pigs, with some exhibiting interstitial fibrosis involving a complete band of subcapsular tissue, while others showed relatively mild changes. There was no apparent change in the vasculature. These findings indicate that (a) there is no one target or dose-limiting cell, and (b) the vasculature does not play a primary role in the development of radiation nephropathy.},
doi = {10.2307/3577921},
url = {https://www.osti.gov/biblio/5760317}, journal = {Radiation Research; (USA)},
issn = {0033-7587},
number = ,
volume = 126:3,
place = {United States},
year = {Sat Jun 01 00:00:00 EDT 1991},
month = {Sat Jun 01 00:00:00 EDT 1991}
}