Genetic characterization of cells of homocystinuria patients with disrupted DNA repair system

Journal Article · Fri Aug 01 00:00:00 EDT 1986 · Sov. Genet. (Engl. Transl.); (United States)

OSTI ID:5758499

Sinel'shchikova, T A; L'vova, G N; Shoniya, N N; Zasukhina, G D

Fibroblasts obtained from biopsy material and lymphocytes of patients with homocystinuria were investigated for repair activity according to the following criteria: rejoined DNA breaks, induced by 4-nitroquinoline-1-oxide and ..gamma..-radiation; indices of reactivation and induced mutagenesis of smallpox vaccine virus treated with these mutagens. In lymphocytes a defect of DNA repair was observed according to all criteria investigated. During passage of fibroblast cultures, inhibition of repair activity of cells was preserved according to ..gamma..-type. Increase in the number of spontaneous and ..gamma..-induced mutations of virus was noted according to degree of passage of fibroblasts.

• Research Organization: N. I. Vavilov Institute of General Genetics, Moscow, USSR
• OSTI ID: 5758499
• Journal Information: Sov. Genet. (Engl. Transl.); (United States), Vol. 22:2; Other Information: Translated from Genetika; 22: No. 2, 322-327(Feb 1986)
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
59 BASIC BIOLOGICAL SCIENCES
FIBROBLASTS
GENETIC RADIATION EFFECTS
TRACER TECHNIQUES
LYMPHOCYTES
NITRO COMPOUNDS
GENETIC EFFECTS
PATIENTS
RADIOTHERAPY
QUINOLINES
STRAND BREAKS
BIOLOGICAL REPAIR
VIRUSES
MUTAGENESIS
GAMMA RADIATION
HEREDITARY DISEASES
HOMOCYSTEINE
LABELLING
METABOLIC DISEASES
MUTATIONS
THYMIDINE
TRITIUM COMPOUNDS
AMINO ACIDS
ANIMAL CELLS
AROMATICS
AZAARENES
AZINES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BLOOD
BLOOD CELLS
BODY FLUIDS
CARBOXYLIC ACIDS
CONNECTIVE TISSUE CELLS
DISEASES
ELECTROMAGNETIC RADIATION
HETEROCYCLIC COMPOUNDS
IONIZING RADIATIONS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LEUKOCYTES
MATERIALS
MEDICINE
MICROORGANISMS
NUCLEAR MEDICINE
NUCLEOSIDES
NUCLEOTIDES
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PARASITES
PYRIDINES
PYRIMIDINES
RADIATION EFFECTS
RADIATIONS
RADIOLOGY
RECOVERY
REPAIR
RIBOSIDES
SOMATIC CELLS
THERAPY
550603* - Medicine- External Radiation in Therapy- (1980-)
550401 - Genetics- Tracer Techniques
550901 - Pathology- Tracer Techniques