Effect of anemia on tumor radiosensitivity under normo and hyperbaric conditions

Journal Article · Sun Nov 01 00:00:00 EST 1987 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(87)90165-9· OSTI ID:5753566

Rojas, A; Stewart, F A; Smith, K A; Soranson, J A; Randhawa, V S; Stratford, M R; Denekamp, J

The effect of chronic anemia on tumor radiosensitivity in a murine tumor has been investigated. Anemia was induced by bilateral kidney irradiation given several months before tumor implantation. Anemic, anemic transfused, and normal non-anemic age-matched tumor bearing animals were irradiated with X rays (2 F/24 hr) either in air, air plus misonidazole, or under hyperbaric oxygen. The most resistant response was that of tumors grown in normal mice treated in air. Anemia produced an increase in radiosensitivity which was further enhanced by red blood cell replacement. The most sensitive overall response was seen in the anemic-transfused group treated with HBO.

• Research Organization: Mount Vernon Hospital, Northwood, Middlesex, England
• OSTI ID: 5753566
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 13:11
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANEMIAS
RADIOINDUCTION
RADIOSENSITIVITY EFFECTS
EXPERIMENTAL NEOPLASMS
RADIOSENSITIVITY
AIR
KIDNEYS
MICE
MISONIDAZOLE
TRANSFUSIONS
X RADIATION
ANIMALS
ANTINEOPLASTIC DRUGS
AZOLES
BODY
DISEASES
DRUGS
ELECTROMAGNETIC RADIATION
FLUIDS
GASES
HEMIC DISEASES
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
IONIZING RADIATIONS
MAMMALS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
RADIATIONS
RADIOSENSITIZERS
RODENTS
SYMPTOMS
THERAPY
VERTEBRATES
560152* - Radiation Effects on Animals- Animals