Coinhibition of viral interferon induction by Benzo(. alpha. )pyrene in association with occupation-related particles

Journal Article · Fri Jun 01 00:00:00 EDT 1990 · Environmental Research; (United States)

DOI:https://doi.org/10.1016/S0013-9351(05)80153-7· OSTI ID:5740649

Hahon, N ^[1]; Booth, J A ^[2]; Flowers, L ^[3]

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1. National Inst. for Occupational Safety and Health, Morgantown, WV (United States) West Virginia Univ., Morgantown (United States)
2. West Virginia Univ., Morgantown (United States)
3. Univ. of Pennsylvania, Philadelphia (United States)

Benzo({alpha})pyrene (B(a)P) in combination with coal, asbestos, silicate, or metal particles was studied for its inhibitory effects on interferon-{alpha}/{beta} induction by influenza virus in rhesus monkey kidney (LLC-MK{sub 2}) cell monolayers. B(a)P per se had no adverse effect on the induction process. However, when cell cultures were pretreated with B(a)P that was bioactivated by rat liver S9 homogenate, from 52 to 65% inhibition of interferon induction occurred. Significantly greater depression (coinhibition) of viral interferon induction (>83%) resulted when bioactivated B(a)P was incorporated with coal particles representative of coal rank (anthracite, bituminous, lignite, peat). Coinhibition affected by bioactivated B(a)P was coal rank-independent but any interferon inhibitory activity affected by coal particles per se was coal rank-independent. When metals (aluminum, aluminum oxide, ferric oxide, nickel, or chromium) or asbestos fibers were individually mixed with bioactivated B(a)P, coinhibition of cellular interferon synthesis also resulted which was significantly greater than that manifested by bioactivated B(a)P or particles per se. Coinhibition of interferon induction by silicates and the bioactivated hydrocarbon was not in evidence although some silicates alone partially inhibited the induction process. Viral interferon induction was inhibited in a dose-response manner by B(a)P ({+-}S9) in combination with selected particles.

• OSTI ID: 5740649
• Journal Information: Environmental Research; (United States), Vol. 52:1; ISSN 0013-9351
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BENZOPYRENE
TOXICITY
INTERFERON
BIOCHEMICAL REACTION KINETICS
ALUMINIUM
ANIMAL CELLS
ASBESTOS
CELL CULTURES
CHROMIUM
COAL
DOSE-RESPONSE RELATIONSHIPS
IMMUNE REACTIONS
INHIBITION
KIDNEYS
METABOLIC ACTIVATION
METALS
MONKEYS
NICKEL
SILICATES
ANIMALS
AROMATICS
BODY
CARBONACEOUS MATERIALS
CONDENSED AROMATICS
ELEMENTS
ENERGY SOURCES
FOSSIL FUELS
FUELS
GROWTH FACTORS
HYDROCARBONS
KINETICS
LYMPHOKINES
MAMMALS
MATERIALS
MITOGENS
ORGANIC COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
PRIMATES
PROTEINS
REACTION KINETICS
SILICON COMPOUNDS
TRANSITION ELEMENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology